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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0026769,
umls-concept:C0030705,
umls-concept:C0185117,
umls-concept:C0449774,
umls-concept:C0456644,
umls-concept:C0871261,
umls-concept:C1332714,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C1879547,
umls-concept:C1948023,
umls-concept:C2348480,
umls-concept:C2745888,
umls-concept:C2911684,
umls-concept:C2911692
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pubmed:issue |
1-2
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|
pubmed:dateCreated |
2007-9-7
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|
pubmed:abstractText |
Patients with relapsing-remitting (RR) and secondary progressive (SP) forms of multiple sclerosis (MS), although in long-term clinical remission, showed different patterns of increased expressions of the activation markers: CD69, CD40L, and both membrane/surface and cytoplasmic CTLA-4 (mCTLA-4 and cCTLA-4, respectively) in freshly isolated peripheral blood (PB) CD4+ T cells compared with controls. Also observed were dysregulated responses to ex vivo stimulation in both groups of MS patients accompanied by increased IFN-gamma synthesis. Our findings may suggest that the mechanisms leading to each clinical form of the disease may be heterogeneous.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Antiviral Agents,
http://linkedlifedata.com/resource/pubmed/chemical/CD40 Ligand,
http://linkedlifedata.com/resource/pubmed/chemical/CD69 antigen,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA-4 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Ionomycin,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins, C-Type
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0165-5728
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
189
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
137-46
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:17669511-Adult,
pubmed-meshheading:17669511-Antigens, CD,
pubmed-meshheading:17669511-Antigens, Differentiation,
pubmed-meshheading:17669511-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:17669511-Antiviral Agents,
pubmed-meshheading:17669511-CD4-Positive T-Lymphocytes,
pubmed-meshheading:17669511-CD40 Ligand,
pubmed-meshheading:17669511-CTLA-4 Antigen,
pubmed-meshheading:17669511-Cells, Cultured,
pubmed-meshheading:17669511-Female,
pubmed-meshheading:17669511-Flow Cytometry,
pubmed-meshheading:17669511-Gene Expression Regulation,
pubmed-meshheading:17669511-Humans,
pubmed-meshheading:17669511-Interferon-gamma,
pubmed-meshheading:17669511-Ionomycin,
pubmed-meshheading:17669511-Lectins, C-Type,
pubmed-meshheading:17669511-Lymphocyte Activation,
pubmed-meshheading:17669511-Male,
pubmed-meshheading:17669511-Middle Aged,
pubmed-meshheading:17669511-Multiple Sclerosis,
pubmed-meshheading:17669511-Statistics, Nonparametric,
pubmed-meshheading:17669511-Time Factors
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pubmed:year |
2007
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pubmed:articleTitle |
Different patterns of activation markers expression and CD4+ T-cell responses to ex vivo stimulation in patients with clinically quiescent multiple sclerosis (MS).
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pubmed:affiliation |
Polish Academy of Sciences, Institute of Immunology and Experimental Therapy, Department of Experimental Therapy, Laboratory of Immunopathology, R. Weigla 12, 53-114 Wroclaw, Poland. kosmacz@immuno.iitd.pan.wroc.pl
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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