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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4-5
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pubmed:dateCreated |
2007-8-2
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pubmed:abstractText |
The predominant mode of HIV-1 transmission is by heterosexual contact. The cervical/vaginal mucosa is the main port of HIV entry in women. A safe and effective topical microbicide against HIV is urgently needed to prevent sexual transmission. Hence, we evaluated griffithsin (GRFT), a 12.7 kDa carbohydrate-binding protein, both native and recombinant GRFT, potently inhibited both CXCR4-and CCR5-tropic HIV infection and transmission in vitro.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0047-2565
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
36
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
244-53
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pubmed:dateRevised |
2007-12-3
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pubmed:meshHeading |
pubmed-meshheading:17669213-Algal Proteins,
pubmed-meshheading:17669213-Animals,
pubmed-meshheading:17669213-Anti-HIV Agents,
pubmed-meshheading:17669213-Cell Line,
pubmed-meshheading:17669213-Cell Survival,
pubmed-meshheading:17669213-Disease Models, Animal,
pubmed-meshheading:17669213-Female,
pubmed-meshheading:17669213-HIV Infections,
pubmed-meshheading:17669213-Humans,
pubmed-meshheading:17669213-Hydrogen-Ion Concentration,
pubmed-meshheading:17669213-Kinetics,
pubmed-meshheading:17669213-Lectins,
pubmed-meshheading:17669213-Macaca nemestrina,
pubmed-meshheading:17669213-Receptors, CCR5,
pubmed-meshheading:17669213-Receptors, CXCR4,
pubmed-meshheading:17669213-Simian Acquired Immunodeficiency Syndrome,
pubmed-meshheading:17669213-Simian immunodeficiency virus,
pubmed-meshheading:17669213-Vaginal Douching
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pubmed:year |
2007
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pubmed:articleTitle |
Griffithsin, a potent HIV entry inhibitor, is an excellent candidate for anti-HIV microbicide.
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pubmed:affiliation |
Washington National Primate Research Center, University of Washington, Seattle, WA 98195, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural,
Research Support, N.I.H., Intramural
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