|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0012854,
umls-concept:C0013682,
umls-concept:C0017710,
umls-concept:C0019929,
umls-concept:C0024109,
umls-concept:C0026809,
umls-concept:C0032136,
umls-concept:C0332161,
umls-concept:C0599894,
umls-concept:C0600508,
umls-concept:C1517499
|
|
pubmed:issue |
9
|
|
pubmed:dateCreated |
2007-8-27
|
|
pubmed:abstractText |
It has been previously demonstrated that plasmid DNA transport into the nucleus could be increased by transcription factor binding. We chose the glucocorticoid responsive element (GRE) which binds to the glucocorticoid receptor (GR), a transcription factor which is shuttled into the nucleus upon ligand binding such as dexamethasone.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
1099-498X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
9
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
820-9
|
|
pubmed:meshHeading |
pubmed-meshheading:17668918-Aerosols,
pubmed-meshheading:17668918-Animals,
pubmed-meshheading:17668918-COS Cells,
pubmed-meshheading:17668918-Cell Line, Tumor,
pubmed-meshheading:17668918-Cell Nucleus,
pubmed-meshheading:17668918-Cercopithecus aethiops,
pubmed-meshheading:17668918-DNA,
pubmed-meshheading:17668918-Dexamethasone,
pubmed-meshheading:17668918-Electrophoretic Mobility Shift Assay,
pubmed-meshheading:17668918-Epithelial Cells,
pubmed-meshheading:17668918-Gene Transfer Techniques,
pubmed-meshheading:17668918-Green Fluorescent Proteins,
pubmed-meshheading:17668918-Humans,
pubmed-meshheading:17668918-Injections,
pubmed-meshheading:17668918-Luciferases,
pubmed-meshheading:17668918-Lung,
pubmed-meshheading:17668918-Mice,
pubmed-meshheading:17668918-Plasmids,
pubmed-meshheading:17668918-Polyethyleneimine,
pubmed-meshheading:17668918-Protein Transport,
pubmed-meshheading:17668918-Receptors, Glucocorticoid,
pubmed-meshheading:17668918-Response Elements,
pubmed-meshheading:17668918-Tail,
pubmed-meshheading:17668918-Viruses
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
Targeting of the glucocorticoid hormone receptor with plasmid DNA comprising glucocorticoid response elements improves nonviral gene transfer efficiency in the lungs of mice.
|
|
pubmed:affiliation |
Department of Pediatrics, Ludwig-Maximilians University, Lindwurmstrasse 2a, 80337, Munich, Germany.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
