Source:http://linkedlifedata.com/resource/pubmed/id/17668444
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2008-1-28
|
| pubmed:abstractText |
Marlin-1 is a GABA(B) receptor and Jak tyrosine kinase-binding protein that also associates with RNA and microtubules. In humans and rodents, expression of Marlin-1 is predominantly restricted to the brain, but expression in lymphoid cells has also been reported. Here, we have studied the distribution of Marlin-1 in testis and spermatozoa. Our results indicate that Marlin-1 is highly expressed in testis. The protein is abundant in spermatogonia, spermatocytes, spermatozoa, and Sertoli cells. We also have studied the subcellular distribution in spermatozoa. Marlin-1 is present in the tail and to a lesser degree in the head of the sperm cell. Finally, we have explored two protein interactions. Our findings demonstrate that Marlin-1 associates with a microtubule fraction and with GABA(B) receptors in testis suggesting that the set of protein interactions of Marlin-1 are conserved in different tissues.
|
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
1097-4644
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright 2007 Wiley-Liss, Inc.
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| pubmed:issnType |
Electronic
|
| pubmed:day |
15
|
| pubmed:volume |
103
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
886-95
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| pubmed:meshHeading |
pubmed-meshheading:17668444-Animals,
pubmed-meshheading:17668444-Cytoskeleton,
pubmed-meshheading:17668444-Immunohistochemistry,
pubmed-meshheading:17668444-Immunoprecipitation,
pubmed-meshheading:17668444-Male,
pubmed-meshheading:17668444-Mice,
pubmed-meshheading:17668444-Mice, Inbred BALB C,
pubmed-meshheading:17668444-Microtubule-Associated Proteins,
pubmed-meshheading:17668444-Microtubules,
pubmed-meshheading:17668444-Protein Binding,
pubmed-meshheading:17668444-RNA-Binding Proteins,
pubmed-meshheading:17668444-Rats,
pubmed-meshheading:17668444-Rats, Sprague-Dawley,
pubmed-meshheading:17668444-Receptors, GABA-B,
pubmed-meshheading:17668444-Sertoli Cells,
pubmed-meshheading:17668444-Spermatogenesis,
pubmed-meshheading:17668444-Spermatozoa,
pubmed-meshheading:17668444-Testis,
pubmed-meshheading:17668444-Tissue Distribution
|
| pubmed:year |
2008
|
| pubmed:articleTitle |
Marlin-1 is expressed in testis and associates to the cytoskeleton and GABAB receptors.
|
| pubmed:affiliation |
Institute of Biochemistry, Universidad Austral de Chile, Isla Teja, Valdivia, Chile.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|