Source:http://linkedlifedata.com/resource/pubmed/id/17668246
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
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| pubmed:dateCreated |
2007-8-27
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| pubmed:abstractText |
The concentration of cystatin C has been shown to be independent of age, gender and height, but the effect of malnutrition has not been studied. Levels of serum creatinine and cystatin C were estimated in 77 malnourished and 77 normally nourished boys between 2 years and 6 years of age without evidence of renal disease. The mean (95% confidence interval) serum creatinine level in the malnourished boys was significantly lower than that in the normally nourished boys [0.42 (0.38-0.45) mg/dl and 0.51 (0.48-0.55)] mg/dl, respectively, (P < 0.01)]. The mean level of serum cystatin C was 1.05 (0.94-1.17) mg/l and 1.12 (1.01-1.24) mg/l, respectively, in normally nourished and malnourished boys (P = 0.35). Mean glomerular filtration rate (GFR) estimated by the Schwartz equation in the malnourished boys was significantly higher than that in normally nourished children [141.8 (123.3-160.2) ml/min per 1.73 m(2) body surface area and 119.4 (109.3-129.5) ml/min per 1.73 m(2) body surface area], respectively (P = 0.04). However, the mean cystatin C-derived GFR was similar in the malnourished and normally nourished boys [99.70 (85.8-113.5) ml/min per 1.73 m(2) and 109.2 (94.4-124.0) ml/min per 1.73 m(2)], respectively (P = 0.35). The mean bias between GFR estimates using Bland and Altman analysis was greater in the malnourished children than in the normally nourished children (32.3% and 17.6%, respectively) (P = 0.15). Serum creatinine levels are lower in malnourished children and lead to overestimation of GFR, while cystatin C levels are unaffected.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Oct
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| pubmed:issn |
0931-041X
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
22
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1757-61
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:17668246-Child,
pubmed-meshheading:17668246-Child, Preschool,
pubmed-meshheading:17668246-Creatinine,
pubmed-meshheading:17668246-Cystatin C,
pubmed-meshheading:17668246-Cystatins,
pubmed-meshheading:17668246-Diet,
pubmed-meshheading:17668246-Glomerular Filtration Rate,
pubmed-meshheading:17668246-Humans,
pubmed-meshheading:17668246-Male,
pubmed-meshheading:17668246-Malnutrition,
pubmed-meshheading:17668246-Reference Values
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| pubmed:year |
2007
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| pubmed:articleTitle |
Effect of malnutrition on serum creatinine and cystatin C levels.
|
| pubmed:affiliation |
Department of Pediatrics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India. pankajhari@hotmail.com
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| pubmed:publicationType |
Journal Article
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