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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0108779,
umls-concept:C0185117,
umls-concept:C0205263,
umls-concept:C0253023,
umls-concept:C0439098,
umls-concept:C0684249,
umls-concept:C1539477,
umls-concept:C1704259,
umls-concept:C1705987,
umls-concept:C2610891,
umls-concept:C2911684
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pubmed:issue |
3
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pubmed:dateCreated |
2007-12-20
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pubmed:abstractText |
Non-small cell lung carcinoma (NSCLC) patients have impaired cellular immune responses. It has been hypothesized that tumor cells expressing Fas Ligand (FasL) induce in T lymphocytes: (a) apoptosis (tumor counterattack) and (b) down-regulation of CD3zeta expression. However, the hypothesis of tumor counterattack is still controversial.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD28,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD3,
http://linkedlifedata.com/resource/pubmed/chemical/CD3 antigen, zeta chain,
http://linkedlifedata.com/resource/pubmed/chemical/CD3E protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Fas Ligand Protein,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0340-7004
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
57
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
325-36
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pubmed:meshHeading |
pubmed-meshheading:17668204-Adult,
pubmed-meshheading:17668204-Aged,
pubmed-meshheading:17668204-Antigens, CD28,
pubmed-meshheading:17668204-Antigens, CD3,
pubmed-meshheading:17668204-Apoptosis,
pubmed-meshheading:17668204-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:17668204-Cell Line, Tumor,
pubmed-meshheading:17668204-Coculture Techniques,
pubmed-meshheading:17668204-Down-Regulation,
pubmed-meshheading:17668204-Fas Ligand Protein,
pubmed-meshheading:17668204-Flow Cytometry,
pubmed-meshheading:17668204-Humans,
pubmed-meshheading:17668204-Immunohistochemistry,
pubmed-meshheading:17668204-Jurkat Cells,
pubmed-meshheading:17668204-Lung Neoplasms,
pubmed-meshheading:17668204-Middle Aged,
pubmed-meshheading:17668204-RNA, Messenger,
pubmed-meshheading:17668204-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:17668204-Signal Transduction,
pubmed-meshheading:17668204-T-Lymphocytes
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pubmed:year |
2008
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pubmed:articleTitle |
Lung carcinomas do not induce T-cell apoptosis via the Fas/Fas ligand pathway but down-regulate CD3 epsilon expression.
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pubmed:affiliation |
Departamento de Enfermedades Cronico-Degenerativas, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Tlalpan 4502, Col. Seccion XVI, CP 14080 Mexico City, Mexico.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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