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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2007-8-1
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pubmed:abstractText |
Epicutaneously administered chemical antigens like 2,4-dinitrofluorobenzene (DNFB), evoke an atopic dermatitis (AD)-like dermatitis reaction in NC/Nga mice under specific pathogen free (SPF) conditions. Astragalus membranaceus (AM), is a popular herbal medicine used to treat allergic diseases in East Asia. In the present study, we examined whether AM suppress AD-like skin lesions in NC/Nga mice treated with DNFB under SPF conditions. Oral administration of AM to DNFB-treated NC/Nga mice was found to inhibit ear thickness increases and the skin lesions induced by DNFB. Moreover, IFN-gamma production by CD4(+) T cells from the lymph nodes of DNFB-treated NC/Nga mice was significantly inhibited by AM treatment, although levels of IL-4 and total IgE in serum were not. Study findings suggest that AM may suppress the development of AD-like dermatitis in DNFB-treated NC/Nga mice by reducing IFN-gamma production.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0918-6158
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1468-71
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:17666805-Animals,
pubmed-meshheading:17666805-Anti-Inflammatory Agents,
pubmed-meshheading:17666805-Astragalus membranaceus,
pubmed-meshheading:17666805-CD4-Positive T-Lymphocytes,
pubmed-meshheading:17666805-Cytokines,
pubmed-meshheading:17666805-Dermatitis, Atopic,
pubmed-meshheading:17666805-Dinitrofluorobenzene,
pubmed-meshheading:17666805-Ear, External,
pubmed-meshheading:17666805-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:17666805-Female,
pubmed-meshheading:17666805-Immunoglobulin E,
pubmed-meshheading:17666805-Interferon-gamma,
pubmed-meshheading:17666805-Interleukin-4,
pubmed-meshheading:17666805-Mice,
pubmed-meshheading:17666805-Mice, Inbred Strains,
pubmed-meshheading:17666805-Prednisolone,
pubmed-meshheading:17666805-Skin
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pubmed:year |
2007
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pubmed:articleTitle |
Oral administration of Astragalus membranaceus inhibits the development of DNFB-induced dermatitis in NC/Nga mice.
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pubmed:affiliation |
Department of Microbiology (BK21), College of Medicine, Kyung Hee University, #1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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