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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2007-9-4
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pubmed:abstractText |
The hypereosinophilic syndrome (HES) may be associated with the fusion of the platelet derived growth factor receptor a (PDGFRalpha) gene with the FIP1L1 gene in chromosome 4 coding for a constitutively activated PDGFRalpha tyrosine kinase. These cases with FIP1L1-PDGFRalpha rearrangement have been reported to be very sensitive to the tyrosine kinase inhibitor imatinib mesylate.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/FIP1L1-PDGFRA fusion protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Proteins, Fusion,
http://linkedlifedata.com/resource/pubmed/chemical/Piperazines,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrimidines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Platelet-Derived Growth...,
http://linkedlifedata.com/resource/pubmed/chemical/imatinib,
http://linkedlifedata.com/resource/pubmed/chemical/mRNA Cleavage and Polyadenylation...
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1592-8721
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pubmed:author |
pubmed-author:AstolfiCinziaC,
pubmed-author:BaccaraniMicheleM,
pubmed-author:BuccisanoFrancescoF,
pubmed-author:CilloniDanielaD,
pubmed-author:GiuglianoEmiliaE,
pubmed-author:GottardiEnricoE,
pubmed-author:IacobucciIlariaI,
pubmed-author:MartinelliGiovanniG,
pubmed-author:MeranteSerenaS,
pubmed-author:MessaFrancescaF,
pubmed-author:OttavianiEmanuelaE,
pubmed-author:PaneFabrizioF,
pubmed-author:PaoliniStefaniaS,
pubmed-author:RancatiFrancescaF,
pubmed-author:RondoniMichelaM,
pubmed-author:RostiGianantonioG,
pubmed-author:SaglioGiuseppeG,
pubmed-author:SoveriniSimonaS,
pubmed-author:TestoniNicolettaN,
pubmed-author:TiribelliMarioM,
pubmed-author:de VivoAntonioA
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pubmed:issnType |
Electronic
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pubmed:volume |
92
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1173-9
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17666373-Adolescent,
pubmed-meshheading:17666373-Adult,
pubmed-meshheading:17666373-Aged,
pubmed-meshheading:17666373-Aged, 80 and over,
pubmed-meshheading:17666373-Antineoplastic Agents,
pubmed-meshheading:17666373-Female,
pubmed-meshheading:17666373-Gene Rearrangement,
pubmed-meshheading:17666373-Humans,
pubmed-meshheading:17666373-Hypereosinophilic Syndrome,
pubmed-meshheading:17666373-Male,
pubmed-meshheading:17666373-Middle Aged,
pubmed-meshheading:17666373-Oncogene Proteins, Fusion,
pubmed-meshheading:17666373-Piperazines,
pubmed-meshheading:17666373-Prospective Studies,
pubmed-meshheading:17666373-Protein-Tyrosine Kinases,
pubmed-meshheading:17666373-Pyrimidines,
pubmed-meshheading:17666373-Receptor, Platelet-Derived Growth Factor alpha,
pubmed-meshheading:17666373-Treatment Outcome,
pubmed-meshheading:17666373-mRNA Cleavage and Polyadenylation Factors
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pubmed:year |
2007
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pubmed:articleTitle |
The efficacy of imatinib mesylate in patients with FIP1L1-PDGFRalpha-positive hypereosinophilic syndrome. Results of a multicenter prospective study.
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pubmed:affiliation |
Department of Hematology-Oncology L. and A. Seràgnoli, S.Orsola-Malpighi University Hospital, Bologna, Italy. michele.baccarani@unibo.it
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Multicenter Study
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