Linked Life Data

17664560

Source:http://linkedlifedata.com/resource/pubmed/id/17664560

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2007-7-31
pubmed:abstractText
Existing studies have suggested some debate on whether the quality of radiation that delivers dose outside of the primary field of a radiotherapy photon beam can be considered the same as that inside the primary field. We used a Monte Carlo approach to simulate the electron fluence differential in energy inside a water phantom in response to irradiation by a 6 MV photon beam. The goal was to quantify how significantly the electron fluence changes when moving from a volume exposed to the primary field to one outside of the primary field, and understand any potential biological implications. We scored the electron fluence outwards in annular volumes in response to a 5 cm radius 6 MV beam and at the central axis in response to a rectangular 6 MV beam partially blocked by an MLC. The resulting fluence spectra were compared to different low-LET sources for which biological response in the form of chromosomal aberrations has been published. Our results show a significant increase in the low energy component of the fluence spectra outside of the primary field, which increases the mean LET to values similar to that seen in response to a 137Cs photon source. In turn, it is shown that this has the potential to increase the RBE.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0031-9155
pubmed:author
pubmed:issnType
Print
pubmed:day
21
pubmed:volume
52
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3563-78
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
A Monte Carlo study of the variation of electron fluence in water from a 6 MV photon beam outside of the field.
pubmed:affiliation
Department of Medical Physics, Cross Cancer Institute, University of Alberta, 11560 University Avenue, Edmonton, Alberta, T6G1Z2, Canada. ckirkby@phys.ualberta.ca
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't