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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
22
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pubmed:dateCreated |
2007-7-31
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pubmed:abstractText |
In a previous cohort study, we proposed that responsiveness of metastatic colorectal cancer (mCRC) to anti-epidermal growth factor receptor (EGFR) monoclonal antibodies has a genetic basis, being associated with increased EGFR gene copy number (GCN) as measured by fluorescence in situ hybridization (FISH) in individual tumors. The present study was aimed at assessing the predictive role of EGFR GCN, in terms of clinical outcome, in patients treated with panitumumab.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1527-7755
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pubmed:author |
pubmed-author:BajettaEmilioE,
pubmed-author:BaroneCarloC,
pubmed-author:CarnaghiCarloC,
pubmed-author:CascinuStefanoS,
pubmed-author:ColucciGiuseppeG,
pubmed-author:CortesiEnricoE,
pubmed-author:GambacortaMarcelloM,
pubmed-author:LuppiGabrieleG,
pubmed-author:MoroniMauroM,
pubmed-author:NichelattiMicheleM,
pubmed-author:Sartore-BianchiAndreaA,
pubmed-author:SienaSalvatoreS,
pubmed-author:SobreroAlbertoA,
pubmed-author:VeroneseSilvioS
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3238-45
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pubmed:meshHeading |
pubmed-meshheading:17664472-Adult,
pubmed-meshheading:17664472-Aged,
pubmed-meshheading:17664472-Antibodies, Monoclonal,
pubmed-meshheading:17664472-Antineoplastic Agents,
pubmed-meshheading:17664472-Colorectal Neoplasms,
pubmed-meshheading:17664472-Female,
pubmed-meshheading:17664472-Genes, erbB-1,
pubmed-meshheading:17664472-Humans,
pubmed-meshheading:17664472-In Situ Hybridization, Fluorescence,
pubmed-meshheading:17664472-Italy,
pubmed-meshheading:17664472-Logistic Models,
pubmed-meshheading:17664472-Male,
pubmed-meshheading:17664472-Middle Aged,
pubmed-meshheading:17664472-Neoplasm Metastasis,
pubmed-meshheading:17664472-ROC Curve,
pubmed-meshheading:17664472-Survival Rate,
pubmed-meshheading:17664472-Treatment Outcome
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pubmed:year |
2007
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pubmed:articleTitle |
Epidermal growth factor receptor gene copy number and clinical outcome of metastatic colorectal cancer treated with panitumumab.
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pubmed:affiliation |
Divisione Oncologia Falck, Ospedale Niguarda Ca' Granda, Piazza Ospedale Maggiore 3, 20162 Milan, Italy. salvatore.siena@ospedaleniguarda.it
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study,
Clinical Trial, Phase III
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