| pubmed-article:17664435 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17664435 | lifeskim:mentions | umls-concept:C0006644 | lld:lifeskim |
| pubmed-article:17664435 | lifeskim:mentions | umls-concept:C0040300 | lld:lifeskim |
| pubmed-article:17664435 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:17664435 | lifeskim:mentions | umls-concept:C0015677 | lld:lifeskim |
| pubmed-article:17664435 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:17664435 | lifeskim:mentions | umls-concept:C0442027 | lld:lifeskim |
| pubmed-article:17664435 | lifeskim:mentions | umls-concept:C0015259 | lld:lifeskim |
| pubmed-article:17664435 | lifeskim:mentions | umls-concept:C1519755 | lld:lifeskim |
| pubmed-article:17664435 | lifeskim:mentions | umls-concept:C0439656 | lld:lifeskim |
| pubmed-article:17664435 | lifeskim:mentions | umls-concept:C0547047 | lld:lifeskim |
| pubmed-article:17664435 | lifeskim:mentions | umls-concept:C0522501 | lld:lifeskim |
| pubmed-article:17664435 | pubmed:issue | 31 | lld:pubmed |
| pubmed-article:17664435 | pubmed:dateCreated | 2007-8-1 | lld:pubmed |
| pubmed-article:17664435 | pubmed:abstractText | Treatment of SKH-1 mice orally with caffeine (0.1 mg/ml in the drinking water), voluntary running wheel exercise, or a combination of caffeine and exercise for 2 weeks (i) decreased the weight of the parametrial fat pads by 35, 62, and 77%, respectively; (ii) decreased the thickness of the dermal fat layer by 38, 42, and 68%, respectively; (iii) stimulated the formation of UVB-induced apoptotic sunburn cells in the epidermis by 96, 120, and 376%, respectively; and (iv) stimulated the formation of UVB-induced caspase 3 (active form)-positive cells in the epidermis by 92, 120, and 389%, respectively (average of two experiments). Oral administration of caffeine (0.4 mg/ml in the drinking water) in combination with voluntary exercise was less effective than administration of the low dose of caffeine in combination with exercise in stimulating UVB-induced apoptosis. Although orally administrated caffeine (0.1 mg/ml in the drinking water) or voluntary exercise for 2 weeks caused only a small nonsignificant stimulation of UVB-induced increase in the percentage of phospho-p53 (Ser-15)-positive cells in the epidermis (27 or 18%, respectively), the combination of the two treatments enhanced the UVB-induced increase in phospho-p53 (Ser-15)-positive cells by 99%. The plasma concentration of caffeine in mice ingesting caffeine (0.1-0.4 mg/ml drinking water) is similar to that in the plasma of most coffee drinkers (one to four cups per day). Our studies indicate a greater than additive stimulatory effect of combined voluntary exercise and oral administration of a low dose of caffeine on UVB-induced apoptosis. | lld:pubmed |
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| pubmed-article:17664435 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:17664435 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17664435 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17664435 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:17664435 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:17664435 | pubmed:author | pubmed-author:ConneyAllan... | lld:pubmed |
| pubmed-article:17664435 | pubmed:author | pubmed-author:WagnerGeorge... | lld:pubmed |
| pubmed-article:17664435 | pubmed:author | pubmed-author:LuYao-PingYP | lld:pubmed |
| pubmed-article:17664435 | pubmed:author | pubmed-author:LouYou-RongYR | lld:pubmed |
| pubmed-article:17664435 | pubmed:author | pubmed-author:PengQing-YunQ... | lld:pubmed |
| pubmed-article:17664435 | pubmed:author | pubmed-author:NolanBonnieB | lld:pubmed |
| pubmed-article:17664435 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17664435 | pubmed:day | 31 | lld:pubmed |
| pubmed-article:17664435 | pubmed:volume | 104 | lld:pubmed |
| pubmed-article:17664435 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17664435 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17664435 | pubmed:pagination | 12936-41 | lld:pubmed |
| pubmed-article:17664435 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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