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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2007-9-28
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pubmed:abstractText |
Fibroblast growth factor (FGF) family signaling largely controls cellular homeostasis through short-range intercell paracrine communication. Recently FGF15/19, 21, and 23 have been implicated in endocrine control of metabolic homeostasis. The identity and location of the FGF receptor isotypes that mediate these effects are unclear. The objective was to determine the role of FGFR4, an isotype that has been proposed to mediate an ileal FGF15/19 to hepatocyte FGFR4 axis in cholesterol homeostasis, in metabolic homeostasis in vivo.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Dietary Fats,
http://linkedlifedata.com/resource/pubmed/chemical/FGFR4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Fgfr4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Lipids,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Fibroblast Growth...
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1939-327X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
56
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2501-10
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:17664243-Adipose Tissue,
pubmed-meshheading:17664243-Animals,
pubmed-meshheading:17664243-Blood Glucose,
pubmed-meshheading:17664243-Body Weight,
pubmed-meshheading:17664243-Dietary Fats,
pubmed-meshheading:17664243-Fatty Liver,
pubmed-meshheading:17664243-Gene Expression Regulation,
pubmed-meshheading:17664243-Glucose,
pubmed-meshheading:17664243-Homeostasis,
pubmed-meshheading:17664243-Hyperlipidemias,
pubmed-meshheading:17664243-Insulin,
pubmed-meshheading:17664243-Insulin Resistance,
pubmed-meshheading:17664243-Lipids,
pubmed-meshheading:17664243-Liver,
pubmed-meshheading:17664243-Mice,
pubmed-meshheading:17664243-Mice, Knockout,
pubmed-meshheading:17664243-Mice, Transgenic,
pubmed-meshheading:17664243-Organ Size,
pubmed-meshheading:17664243-RNA, Messenger,
pubmed-meshheading:17664243-Receptor, Fibroblast Growth Factor, Type 4
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pubmed:year |
2007
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pubmed:articleTitle |
FGFR4 prevents hyperlipidemia and insulin resistance but underlies high-fat diet induced fatty liver.
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pubmed:affiliation |
Center for Cancer and Stem Cell Biology, Institute of Biosciences and Technology, Texas A&M Health Science Center, 2121 W. Holcombe Blvd., Houston, TX 77030, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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