| pubmed-article:17664138 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17664138 | lifeskim:mentions | umls-concept:C0003402 | lld:lifeskim |
| pubmed-article:17664138 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:17664138 | lifeskim:mentions | umls-concept:C0024501 | lld:lifeskim |
| pubmed-article:17664138 | lifeskim:mentions | umls-concept:C1522564 | lld:lifeskim |
| pubmed-article:17664138 | lifeskim:mentions | umls-concept:C0013089 | lld:lifeskim |
| pubmed-article:17664138 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:17664138 | lifeskim:mentions | umls-concept:C0065331 | lld:lifeskim |
| pubmed-article:17664138 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:17664138 | pubmed:dateCreated | 2007-7-31 | lld:pubmed |
| pubmed-article:17664138 | pubmed:abstractText | The mechanism of doxorubicin-induced cardiotoxicity remains controversial. Wistar rats (n=96) were randomly assigned to a control (C), lycopene (L), doxorubicin (D), or doxorubicin+lycopene (DL) group. The L and DL groups received lycopene (5 mg/kg body wt/day by gavage) for 7 weeks. The D and DL groups received doxorubicin (4 mg/kg body wt intraperitoneally) at 3, 4, 5, and 6 weeks and were killed at 7 weeks for analyses. Myocardial tissue lycopene levels and total antioxidant performance (TAP) were analyzed by HPLC and fluorometry, respectively. Lycopene metabolism was determined by incubating (2)H(10)-lycopene with intestinal mucosa postmitochondrial fraction and lipoxygenase and analyzed with HPLC and APCI mass spectroscopy. Myocardial tissue lycopene levels in DL and L were similar. TAP adjusted for tissue protein were higher in myocardium of D than those of C (P=0.002). Lycopene metabolism study identified a lower oxidative cleavage of lycopene in D as compared to those of C. Our results showed that lycopene was not depleted in myocardium of lycopene-supplemented rats treated with doxorubicin and that higher antioxidant capacity in myocardium and less oxidative cleavage of lycopene in intestinal mucosa of doxorubicin-treated rats suggest an antioxidant role of doxorubicin rather than acting as a prooxidant. | lld:pubmed |
| pubmed-article:17664138 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17664138 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17664138 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17664138 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17664138 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17664138 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17664138 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17664138 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17664138 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17664138 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17664138 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17664138 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:17664138 | pubmed:issn | 0891-5849 | lld:pubmed |
| pubmed-article:17664138 | pubmed:author | pubmed-author:KrinskyNorman... | lld:pubmed |
| pubmed-article:17664138 | pubmed:author | pubmed-author:YeumKyung-Jin... | lld:pubmed |
| pubmed-article:17664138 | pubmed:author | pubmed-author:TangGuangwenG | lld:pubmed |
| pubmed-article:17664138 | pubmed:author | pubmed-author:MatsubaraBeat... | lld:pubmed |
| pubmed-article:17664138 | pubmed:author | pubmed-author:MatsubaraLuiz... | lld:pubmed |
| pubmed-article:17664138 | pubmed:author | pubmed-author:FerreiraAna... | lld:pubmed |
| pubmed-article:17664138 | pubmed:author | pubmed-author:CorreaCamila... | lld:pubmed |
| pubmed-article:17664138 | pubmed:author | pubmed-author:PereiraEleniz... | lld:pubmed |
| pubmed-article:17664138 | pubmed:author | pubmed-author:RussellRobert... | lld:pubmed |
| pubmed-article:17664138 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17664138 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:17664138 | pubmed:volume | 43 | lld:pubmed |
| pubmed-article:17664138 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17664138 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17664138 | pubmed:pagination | 740-51 | lld:pubmed |
| pubmed-article:17664138 | pubmed:meshHeading | pubmed-meshheading:17664138... | lld:pubmed |
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| pubmed-article:17664138 | pubmed:meshHeading | pubmed-meshheading:17664138... | lld:pubmed |
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| pubmed-article:17664138 | pubmed:meshHeading | pubmed-meshheading:17664138... | lld:pubmed |
| pubmed-article:17664138 | pubmed:meshHeading | pubmed-meshheading:17664138... | lld:pubmed |
| pubmed-article:17664138 | pubmed:meshHeading | pubmed-meshheading:17664138... | lld:pubmed |
| pubmed-article:17664138 | pubmed:meshHeading | pubmed-meshheading:17664138... | lld:pubmed |
| pubmed-article:17664138 | pubmed:meshHeading | pubmed-meshheading:17664138... | lld:pubmed |
| pubmed-article:17664138 | pubmed:meshHeading | pubmed-meshheading:17664138... | lld:pubmed |
| pubmed-article:17664138 | pubmed:meshHeading | pubmed-meshheading:17664138... | lld:pubmed |
| pubmed-article:17664138 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17664138 | pubmed:articleTitle | Doxorubicin as an antioxidant: maintenance of myocardial levels of lycopene under doxorubicin treatment. | lld:pubmed |
| pubmed-article:17664138 | pubmed:affiliation | Department of Internal Medicine, Botucatu Faculty of Medicine, UNESP, São Paulo State University, CEP: 18618-970, Botucatu, SP, Brazil. ferreira@fmb.unesp.br | lld:pubmed |
| pubmed-article:17664138 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17664138 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:17664138 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
