Source:http://linkedlifedata.com/resource/pubmed/id/17664138
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2007-7-31
|
| pubmed:abstractText |
The mechanism of doxorubicin-induced cardiotoxicity remains controversial. Wistar rats (n=96) were randomly assigned to a control (C), lycopene (L), doxorubicin (D), or doxorubicin+lycopene (DL) group. The L and DL groups received lycopene (5 mg/kg body wt/day by gavage) for 7 weeks. The D and DL groups received doxorubicin (4 mg/kg body wt intraperitoneally) at 3, 4, 5, and 6 weeks and were killed at 7 weeks for analyses. Myocardial tissue lycopene levels and total antioxidant performance (TAP) were analyzed by HPLC and fluorometry, respectively. Lycopene metabolism was determined by incubating (2)H(10)-lycopene with intestinal mucosa postmitochondrial fraction and lipoxygenase and analyzed with HPLC and APCI mass spectroscopy. Myocardial tissue lycopene levels in DL and L were similar. TAP adjusted for tissue protein were higher in myocardium of D than those of C (P=0.002). Lycopene metabolism study identified a lower oxidative cleavage of lycopene in D as compared to those of C. Our results showed that lycopene was not depleted in myocardium of lycopene-supplemented rats treated with doxorubicin and that higher antioxidant capacity in myocardium and less oxidative cleavage of lycopene in intestinal mucosa of doxorubicin-treated rats suggest an antioxidant role of doxorubicin rather than acting as a prooxidant.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antioxidants,
http://linkedlifedata.com/resource/pubmed/chemical/Carotenoids,
http://linkedlifedata.com/resource/pubmed/chemical/Doxorubicin,
http://linkedlifedata.com/resource/pubmed/chemical/Oleandomycin,
http://linkedlifedata.com/resource/pubmed/chemical/Tetracycline,
http://linkedlifedata.com/resource/pubmed/chemical/lycopene,
http://linkedlifedata.com/resource/pubmed/chemical/oletetrin
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0891-5849
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| pubmed:author |
pubmed-author:CorreaCamila RCR,
pubmed-author:FerreiraAna Lucia AnjosAL,
pubmed-author:KrinskyNorman INI,
pubmed-author:MatsubaraBeatriz BojikianBB,
pubmed-author:MatsubaraLuiz ShigueroLS,
pubmed-author:PereiraElenize JamasEJ,
pubmed-author:RussellRobert MitchellRM,
pubmed-author:TangGuangwenG,
pubmed-author:YeumKyung-JinKJ
|
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
43
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
740-51
|
| pubmed:meshHeading |
pubmed-meshheading:17664138-Animals,
pubmed-meshheading:17664138-Antioxidants,
pubmed-meshheading:17664138-Carotenoids,
pubmed-meshheading:17664138-Catalysis,
pubmed-meshheading:17664138-Chromatography, Liquid,
pubmed-meshheading:17664138-Doxorubicin,
pubmed-meshheading:17664138-Heart,
pubmed-meshheading:17664138-Kinetics,
pubmed-meshheading:17664138-Lycopersicon esculentum,
pubmed-meshheading:17664138-Male,
pubmed-meshheading:17664138-Mass Spectrometry,
pubmed-meshheading:17664138-Molecular Structure,
pubmed-meshheading:17664138-Myocardium,
pubmed-meshheading:17664138-Oleandomycin,
pubmed-meshheading:17664138-Oxidation-Reduction,
pubmed-meshheading:17664138-Rats,
pubmed-meshheading:17664138-Rats, Wistar,
pubmed-meshheading:17664138-Tetracycline
|
| pubmed:year |
2007
|
| pubmed:articleTitle |
Doxorubicin as an antioxidant: maintenance of myocardial levels of lycopene under doxorubicin treatment.
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| pubmed:affiliation |
Department of Internal Medicine, Botucatu Faculty of Medicine, UNESP, São Paulo State University, CEP: 18618-970, Botucatu, SP, Brazil. ferreira@fmb.unesp.br
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|