Source:http://linkedlifedata.com/resource/pubmed/id/17663739
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
8
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pubmed:dateCreated |
2007-7-31
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pubmed:abstractText |
The tissue-specific pattern of tissue factor (TF) expression suggests that it plays a major role in the hemostatic protection of specific organs, such as the heart and lung. In support of this notion, we found that mice expressing very low levels of TF exhibit hemostatic defects in the heart and lung. Hemosiderosis and fibrosis are observed in the hearts of all low TF mice as early as 3 months of age. In contrast, TF(+/-) mice expressing approximately 50% of wild-type levels of TF had no detectable hemostatic defects.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1538-7933
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1693-700
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pubmed:meshHeading |
pubmed-meshheading:17663739-Animals,
pubmed-meshheading:17663739-Genotype,
pubmed-meshheading:17663739-Heart,
pubmed-meshheading:17663739-Hemostasis,
pubmed-meshheading:17663739-Humans,
pubmed-meshheading:17663739-Isoproterenol,
pubmed-meshheading:17663739-Mice,
pubmed-meshheading:17663739-Mice, Transgenic,
pubmed-meshheading:17663739-Models, Genetic,
pubmed-meshheading:17663739-Myocardium,
pubmed-meshheading:17663739-Myocytes, Cardiac,
pubmed-meshheading:17663739-Thromboplastin,
pubmed-meshheading:17663739-Tissue Distribution
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pubmed:year |
2007
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pubmed:articleTitle |
Role of cardiac myocyte tissue factor in heart hemostasis.
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pubmed:affiliation |
Department of Immunology, The Scripps Research Institute, La Jolla, CA, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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