Linked Life Data

17663169

Source:http://linkedlifedata.com/resource/pubmed/id/17663169

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2007-7-31
pubmed:abstractText
Retrospective study of DNA ploidy was performed on cytologic slides derived from 30 patients with malignant melanoma (stage IV) before interleukin-2 (IL-2) treatment. Twelve patients were tested after two courses of treatment. Diploid tumors were detected in 4, aneuploid - 26. Significant differences in survival versus DNA ploidy (p=0.025) and response to treatment (p=0.016) were found by use of single-factor analysis (Caplan-Meyer). However, multivariate proportional-hazard regression method (Cox) identified high prognostic relevance (p=0.00007) of a combination of 5 factors: DNA ploidy (p=0.008), gender (p=0.015), blood group (p=0.015), sum total of metastasis diameter (p=0.035) and response to treatment (p=0.042). Significant drop in DNA level after treatment was reported in 9 out of 12 patients; no change - 1 and a rise in 2. The post treatment increase involved rapid progression of tumor.
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0507-3758
pubmed:author
pubmed:issnType
Print
pubmed:volume
53
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
164-9
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
[Prognostic significance of DNA ploidy in disseminated malignant skin melanoma and the effectiveness of interleukin-2 (IL-2) treatment].
pubmed:publicationType
Journal Article, English Abstract