| pubmed-article:17662073 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17662073 | lifeskim:mentions | umls-concept:C0023861 | lld:lifeskim |
| pubmed-article:17662073 | lifeskim:mentions | umls-concept:C0534519 | lld:lifeskim |
| pubmed-article:17662073 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:17662073 | lifeskim:mentions | umls-concept:C0007587 | lld:lifeskim |
| pubmed-article:17662073 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:17662073 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:17662073 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:17662073 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:17662073 | pubmed:dateCreated | 2007-12-18 | lld:pubmed |
| pubmed-article:17662073 | pubmed:abstractText | Listeria monocytogenes induces apoptosis in vitro and in vivo in a variety of cell types. However, the mechanism of cell death in L. monocytogenes-infected macrophages was initially reported to be distinct from apoptosis. Here, we studied the mechanism of L. monocytogenes-induced cell death using sensitive fluorescent techniques. We found that caspase-1 activation preceded cell death of macrophages infected with L. monocytogenes, using fluorogenic substrates. Caspase-1 activation was diminished after infection with wild-type L. monocytogenes when cells were treated with NH(4)Cl, or if they were infected with a listeriolysin mutant that cannot escape from the phagolysosome. Mitochondrial membrane integrity was preserved during the infection. A particular mechanism of cell death, recently termed 'pyroptosis', is associated with infection by intracellular microorganisms, and has an inherent pro-inflammatory character, due to involvement of caspase-1 activation with consequent IL-1 beta and IL-18 production. Cell death through caspase-1 activation would constitute a defence mechanism of macrophages which induces cell death to eliminate the bacteria's intracytosolic niche and recruits early host's defences through the secretion of inflammatory cytokines. | lld:pubmed |
| pubmed-article:17662073 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17662073 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17662073 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17662073 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17662073 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17662073 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:17662073 | pubmed:issn | 1462-5822 | lld:pubmed |
| pubmed-article:17662073 | pubmed:author | pubmed-author:NagataToshiT | lld:pubmed |
| pubmed-article:17662073 | pubmed:author | pubmed-author:UchijimaMasat... | lld:pubmed |
| pubmed-article:17662073 | pubmed:author | pubmed-author:KoideYukioY | lld:pubmed |
| pubmed-article:17662073 | pubmed:author | pubmed-author:CervantesJorg... | lld:pubmed |
| pubmed-article:17662073 | pubmed:author | pubmed-author:ShibataKiyosh... | lld:pubmed |
| pubmed-article:17662073 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:17662073 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:17662073 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17662073 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17662073 | pubmed:pagination | 41-52 | lld:pubmed |
| pubmed-article:17662073 | pubmed:meshHeading | pubmed-meshheading:17662073... | lld:pubmed |
| pubmed-article:17662073 | pubmed:meshHeading | pubmed-meshheading:17662073... | lld:pubmed |
| pubmed-article:17662073 | pubmed:meshHeading | pubmed-meshheading:17662073... | lld:pubmed |
| pubmed-article:17662073 | pubmed:meshHeading | pubmed-meshheading:17662073... | lld:pubmed |
| pubmed-article:17662073 | pubmed:meshHeading | pubmed-meshheading:17662073... | lld:pubmed |
| pubmed-article:17662073 | pubmed:meshHeading | pubmed-meshheading:17662073... | lld:pubmed |
| pubmed-article:17662073 | pubmed:meshHeading | pubmed-meshheading:17662073... | lld:pubmed |
| pubmed-article:17662073 | pubmed:meshHeading | pubmed-meshheading:17662073... | lld:pubmed |
| pubmed-article:17662073 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:17662073 | pubmed:articleTitle | Intracytosolic Listeria monocytogenes induces cell death through caspase-1 activation in murine macrophages. | lld:pubmed |
| pubmed-article:17662073 | pubmed:affiliation | Department of Infectious Diseases, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, Shizuoka 431-3192, Japan. | lld:pubmed |
| pubmed-article:17662073 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17662073 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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