Source:http://linkedlifedata.com/resource/pubmed/id/17661426
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
2007-7-30
|
| pubmed:abstractText |
We assessed prospectively clinical and quality of life changes in 9 patients with Parkinson's disease (PD; H&Y > or = 3) with severe motor fluctuations and dyskinesia who started continuous daily levodopa duodenal infusion through percutaneous endoscopic gastrostomy. Seven patients completed the follow-up period. Duration of "off" periods and time with disabling dyskinesia shortened significantly in all patients (P < 0.01). Total daily dose of levodopa infused did not differ from baseline equivalents. There were significant improvements in UPDRS-II (activities of daily living) and -IV (motor complications) in the "on" condition (P < 0.02), and in four PDQ-39 domains (mobility, activities of daily living, stigma, bodily discomfort; P < 0.05). Two patients withdrew for adverse events. Our results demonstrate that a satisfactory therapeutic window can be achieved and maintained for several months in advanced PD patients.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0885-3185
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
22
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1145-9
|
| pubmed:meshHeading |
pubmed-meshheading:17661426-Aged,
pubmed-meshheading:17661426-Aged, 80 and over,
pubmed-meshheading:17661426-Antiparkinson Agents,
pubmed-meshheading:17661426-Carbidopa,
pubmed-meshheading:17661426-Drug Administration Schedule,
pubmed-meshheading:17661426-Drug Therapy, Combination,
pubmed-meshheading:17661426-Duodenum,
pubmed-meshheading:17661426-Dyskinesias,
pubmed-meshheading:17661426-Female,
pubmed-meshheading:17661426-Humans,
pubmed-meshheading:17661426-Infusions, Intravenous,
pubmed-meshheading:17661426-Levodopa,
pubmed-meshheading:17661426-Male,
pubmed-meshheading:17661426-Middle Aged,
pubmed-meshheading:17661426-Parkinson Disease,
pubmed-meshheading:17661426-Prospective Studies,
pubmed-meshheading:17661426-Quality of Life,
pubmed-meshheading:17661426-Questionnaires,
pubmed-meshheading:17661426-Severity of Illness Index,
pubmed-meshheading:17661426-Time Factors,
pubmed-meshheading:17661426-Treatment Outcome
|
| pubmed:year |
2007
|
| pubmed:articleTitle |
Duodenal levodopa infusion for advanced Parkinson's disease: 12-month treatment outcome.
|
| pubmed:affiliation |
Parkinson Institute, Istituti Clinici di Perfezionamento, Milan, Italy. angelo3000@yahoo.com
|
| pubmed:publicationType |
Journal Article,
Clinical Trial
|