|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0205179,
umls-concept:C0445204,
umls-concept:C0871261,
umls-concept:C1517927,
umls-concept:C1527408,
umls-concept:C1551336,
umls-concept:C1559154,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C1882417,
umls-concept:C2698872,
umls-concept:C2911692
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|
pubmed:issue |
9
|
|
pubmed:dateCreated |
2007-9-24
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|
pubmed:abstractText |
Patients with locally advanced T3 rectal tumors who present with complete pathologic response to preoperative chemoradiation have a low rate of local recurrence and an excellent prognosis. Predictive markers for complete pathologic response are needed with the perspective of improving individualized treatment of these patients. This study was designed to investigate the predictive value of a new combination of three gene polymorphisms: thymidylate synthase, epidermal growth factor receptor Sp1-216, and epidermal growth factor A61G.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0012-3706
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
50
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1363-9
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|
pubmed:dateRevised |
2009-11-19
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|
pubmed:meshHeading |
pubmed-meshheading:17661145-Antineoplastic Agents,
pubmed-meshheading:17661145-Colectomy,
pubmed-meshheading:17661145-Combined Modality Therapy,
pubmed-meshheading:17661145-DNA, Neoplasm,
pubmed-meshheading:17661145-Female,
pubmed-meshheading:17661145-Humans,
pubmed-meshheading:17661145-Male,
pubmed-meshheading:17661145-Middle Aged,
pubmed-meshheading:17661145-Neoplasm Staging,
pubmed-meshheading:17661145-Polymerase Chain Reaction,
pubmed-meshheading:17661145-Polymorphism, Genetic,
pubmed-meshheading:17661145-Prognosis,
pubmed-meshheading:17661145-Radiotherapy, Adjuvant,
pubmed-meshheading:17661145-Receptor, Epidermal Growth Factor,
pubmed-meshheading:17661145-Rectal Neoplasms,
pubmed-meshheading:17661145-Thymidylate Synthase
|
|
pubmed:year |
2007
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|
pubmed:articleTitle |
Germline polymorphisms may act as predictors of response to preoperative chemoradiation in locally advanced T3 rectal tumors.
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|
pubmed:affiliation |
Department of Oncology, Vejle Hospital, Vejle, Denmark. Karen-Lise.Garm.Spindler@vgs.regionsyddanmark.dk
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pubmed:publicationType |
Journal Article
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