Linked Life Data

17660802

Source:http://linkedlifedata.com/resource/pubmed/id/17660802

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2007-9-18
pubmed:abstractText
About 25-45% of patients with high-grade osteosarcoma poorly respond to chemotherapy with an increased risk of relapse and the development of metastasis. Therefore, the aim of this study was the evaluation of the prognostic value of eight previously identified drug-regulated candidate genes on osteosarcoma therapy outcome. Gene expression of 8 candidate genes was analyzed in 35 formalin-fixed, paraffin-embedded, laser-microdissected osteosarcoma biopsies. The prognostic value of these genes was evaluated by the correlation of gene expression with therapy outcome, overall survival and event-free survival in univariate and multivariate analysis. Upon univariate analysis, the expression of MALAT-1, IMPDH2, FTL and RHOA significantly correlated with response to chemotherapy. Expression of all four genes was increased in the poor responder group. Upon multivariate analysis, IMPDH2 maintained its independent prognostic value (P=0.025). Concerning the overall survival of the patients, we observed a significant association with the expression of FTL, PHB, ATAD2, ACTN1 and RRM2 as well as lactate dehydrogenase serum levels. In the subgroups of patients with high expression of these genes and those with elevated lactate dehydrogenase levels, the mean overall survival was decreased 1.7-, 1.9-, 2.2-, 2.4-, 1.5- and 4.5-fold, respectively. Except RRM2, all genes and lactate dehydrogenase serum levels remained significant in the multivariate analysis. In addition, the event-free survival was significantly decreased in the subgroups of patients with high FTL, ATAD2 and IMPDH2 expression (1.8-, 6.3- and 2.4-fold, respectively). These data demonstrate that among the identified genes are valuable markers for the prediction of osteosarcoma therapy outcome. Especially IMPDH2 and FTL are promising candidates for the stratification of osteosarcoma patients into low- and high-risk groups. Owing to their involvement in drug action these genes may further be potential targets for the modulation of drug sensitivity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0893-3952
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1085-94
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:17660802-Adolescent, pubmed-meshheading:17660802-Adult, pubmed-meshheading:17660802-Aged, pubmed-meshheading:17660802-Apoferritins, pubmed-meshheading:17660802-Bone Neoplasms, pubmed-meshheading:17660802-Child, pubmed-meshheading:17660802-Disease-Free Survival, pubmed-meshheading:17660802-Female, pubmed-meshheading:17660802-Ferritins, pubmed-meshheading:17660802-Gene Expression, pubmed-meshheading:17660802-Gene Expression Regulation, Neoplastic, pubmed-meshheading:17660802-Genetic Markers, pubmed-meshheading:17660802-Germany, pubmed-meshheading:17660802-Humans, pubmed-meshheading:17660802-IMP Dehydrogenase, pubmed-meshheading:17660802-Male, pubmed-meshheading:17660802-Middle Aged, pubmed-meshheading:17660802-Neoplasm Staging, pubmed-meshheading:17660802-Osteosarcoma, pubmed-meshheading:17660802-RNA, Messenger, pubmed-meshheading:17660802-RNA, Neoplasm, pubmed-meshheading:17660802-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:17660802-Survival Rate
pubmed:year
2007
pubmed:articleTitle
Prognostic significance of drug-regulated genes in high-grade osteosarcoma.
pubmed:affiliation
Department of Experimental Orthopedics, Orthopedic Hospital, University of Heidelberg, Heidelberg, Germany. joerg.fellenberg@ok.uni-hd.de
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't