Linked Life Data

17659824

Source:http://linkedlifedata.com/resource/pubmed/id/17659824

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2007-8-27
pubmed:abstractText
Although a relationship between vinyl chloride monomer (VCM) and liver cirrhosis has been reported, the underlying mechanisms are not clear. Cytochrome P450 2E1 (CYP2E1), aldehyde dehydrogenase 2 (ALDH2) and glutathione S-transferase theta 1 (GSTT1) enzymes are involved in activation and detoxification of VCM, and thus may be important determinants of interindividual susceptibility to VCM-induced liver damage, including liver cirrhosis. The objective of this study was to evaluate if metabolizing genetic polymorphisms could modify individual susceptibility to liver fibrosis of the VCM exposure. CYP2E1, ALDH2, and GSTT1 polymorphisms were determined by the PCR-RFLP method among 320 workers who were employed in five polyvinyl chloride manufacturing plants. Cumulative VCM exposure levels for study subjects were calculated using a job exposure matrix model. Thirteen workers were diagnosed as having liver fibrosis by using ultrasonography. We observed a dose-response trend between VCM exposure and liver fibrosis. Regarding the results on genetic polymorphisms, CYP2E1 c2c2 genotype showed a significant increase in the risk of liver fibrosis as compared to those with CYP2E1 c1c1 or c1c2 genotypes. No differences were observed between GSTT1 and ALDH2 genotypes and liver fibrosis. In summary, our result suggests that genetic polymorphism in CYP2E1 may be responsible for individual differences in susceptibility to liver fibrosis with regard to chronic VCM exposure. Thus, polymorphism analysis of metabolizing enzymes might be useful in the risk assessment of liver damage in workers with VCM exposure.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0300-483X
pubmed:author
pubmed:issnType
Print
pubmed:day
24
pubmed:volume
239
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
34-44
pubmed:meshHeading
pubmed-meshheading:17659824-Adult, pubmed-meshheading:17659824-Air Pollutants, Occupational, pubmed-meshheading:17659824-Aldehyde Dehydrogenase, pubmed-meshheading:17659824-Carcinogens, pubmed-meshheading:17659824-Cytochrome P-450 CYP2E1, pubmed-meshheading:17659824-Dose-Response Relationship, Drug, pubmed-meshheading:17659824-Genetic Predisposition to Disease, pubmed-meshheading:17659824-Genotype, pubmed-meshheading:17659824-Glutathione Transferase, pubmed-meshheading:17659824-Humans, pubmed-meshheading:17659824-Liver Cirrhosis, pubmed-meshheading:17659824-Occupational Exposure, pubmed-meshheading:17659824-Polymorphism, Genetic, pubmed-meshheading:17659824-Polymorphism, Restriction Fragment Length, pubmed-meshheading:17659824-Risk Assessment, pubmed-meshheading:17659824-Taiwan, pubmed-meshheading:17659824-Vinyl Chloride
pubmed:year
2007
pubmed:articleTitle
Effect of the CYP2E1 genotype on vinyl chloride monomer-induced liver fibrosis among polyvinyl chloride workers.
pubmed:affiliation
Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, National Taiwan University, Zhongzheng District, Taipei City, Taiwan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't