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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2007-12-6
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pubmed:abstractText |
Age-related myelin breakdown is most evident in later-myelinating white matter (LMwm) brain regions. This process might degrade cognitive processing speed (CPS) underlying age-related cognitive decline and the predominance of age as a risk factor for Alzheimer's disease (AD). Apolipoprotein E (ApoE) 4 allele is the second most important AD risk factor. We tested the hypothesis that ApoE4 accelerates age-related slowing in CPS through the process of myelin breakdown.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1873-2402
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
62
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1380-7
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pubmed:dateRevised |
2011-3-24
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pubmed:meshHeading |
pubmed-meshheading:17659264-Aged,
pubmed-meshheading:17659264-Aged, 80 and over,
pubmed-meshheading:17659264-Aging,
pubmed-meshheading:17659264-Apolipoproteins E,
pubmed-meshheading:17659264-Chi-Square Distribution,
pubmed-meshheading:17659264-Cognition Disorders,
pubmed-meshheading:17659264-Dementia,
pubmed-meshheading:17659264-Female,
pubmed-meshheading:17659264-Genetic Predisposition to Disease,
pubmed-meshheading:17659264-Humans,
pubmed-meshheading:17659264-Magnetic Resonance Imaging,
pubmed-meshheading:17659264-Male,
pubmed-meshheading:17659264-Middle Aged,
pubmed-meshheading:17659264-Myelin Sheath,
pubmed-meshheading:17659264-Neuropsychological Tests
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pubmed:year |
2007
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pubmed:articleTitle |
Apolipoprotein E affects both myelin breakdown and cognition: implications for age-related trajectories of decline into dementia.
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pubmed:affiliation |
Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA. gbar@ucla.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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