Linked Life Data

17658737

Source:http://linkedlifedata.com/resource/pubmed/id/17658737

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
17
pubmed:dateCreated
2007-8-16
pubmed:abstractText
Integration of computational methods, X-ray crystallography, and structure-activity relationships will be disclosed, which lead to a new class of p38 inhibitors that bind to p38 MAP kinase in a Phe out conformation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0022-2623
pubmed:author
pubmed:issnType
Print
pubmed:day
23
pubmed:volume
50
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4016-26
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:17658737-Animals, pubmed-meshheading:17658737-Binding Sites, pubmed-meshheading:17658737-Biological Availability, pubmed-meshheading:17658737-Computer Simulation, pubmed-meshheading:17658737-Crystallography, X-Ray, pubmed-meshheading:17658737-Drug Design, pubmed-meshheading:17658737-Lipopolysaccharides, pubmed-meshheading:17658737-Male, pubmed-meshheading:17658737-Mice, pubmed-meshheading:17658737-Models, Molecular, pubmed-meshheading:17658737-Niacinamide, pubmed-meshheading:17658737-Protein Kinase Inhibitors, pubmed-meshheading:17658737-Rats, pubmed-meshheading:17658737-Rats, Sprague-Dawley, pubmed-meshheading:17658737-Structure-Activity Relationship, pubmed-meshheading:17658737-Sulfonamides, pubmed-meshheading:17658737-Thiophenes, pubmed-meshheading:17658737-Tumor Necrosis Factor-alpha, pubmed-meshheading:17658737-p38 Mitogen-Activated Protein Kinases
pubmed:year
2007
pubmed:articleTitle
Discovery and optimization of p38 inhibitors via computer-assisted drug design.
pubmed:affiliation
Department of Medicinal Chemistry, Boehringer Ingelheim Pharmaceuticals, Inc., Research and Development Center, Ridgefield, Connecticut 06877, USA. dgoldber@rdg.boehringer-ingelheim.com
pubmed:publicationType
Journal Article