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rdf:type |
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lifeskim:mentions |
umls-concept:C0007577,
umls-concept:C0007578,
umls-concept:C0010453,
umls-concept:C0017262,
umls-concept:C0086418,
umls-concept:C0185117,
umls-concept:C0225336,
umls-concept:C0360714,
umls-concept:C0392756,
umls-concept:C1522318,
umls-concept:C2911684
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pubmed:issue |
6
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pubmed:dateCreated |
2007-10-24
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pubmed:abstractText |
Smoking predisposes to the development of atherosclerosis and of its complications. The mechanisms responsible for these effects are not completely understood. We have investigated whether nicotine might promote a proatherosclerotic state in human coronary endothelial cells (HCAECs), studying the role of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors in preventing these phenomena.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acids, Monounsaturated,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxymethylglutaryl-CoA...,
http://linkedlifedata.com/resource/pubmed/chemical/Indoles,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Adhesion Molecule-1,
http://linkedlifedata.com/resource/pubmed/chemical/Lovastatin,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/Nicotine,
http://linkedlifedata.com/resource/pubmed/chemical/Nicotinic Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Pravastatin,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Reactive Oxygen Species,
http://linkedlifedata.com/resource/pubmed/chemical/Simvastatin,
http://linkedlifedata.com/resource/pubmed/chemical/Superoxide Dismutase,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Cell Adhesion Molecule-1,
http://linkedlifedata.com/resource/pubmed/chemical/fluvastatin,
http://linkedlifedata.com/resource/pubmed/chemical/rhoA GTP-Binding Protein
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pubmed:status |
MEDLINE
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pubmed:issn |
1423-0135
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pubmed:author |
pubmed-author:AngriValeriaV,
pubmed-author:CalabròPaoloP,
pubmed-author:ChiarielloMassimoM,
pubmed-author:CirilloPlinioP,
pubmed-author:De RosaSalvatoreS,
pubmed-author:FiorentinoIsabellaI,
pubmed-author:GargiuloAnnaritaA,
pubmed-author:Musto D'AmoreSergioS,
pubmed-author:PacileoMarioM,
pubmed-author:PetrilloGianlucaG,
pubmed-author:PreveteNellaN,
pubmed-author:SassoLauraL,
pubmed-author:UcciGraziaG
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pubmed:copyrightInfo |
Copyright 2007 S. Karger AG, Basel.
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pubmed:issnType |
Electronic
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pubmed:volume |
44
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
460-70
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pubmed:dateRevised |
2010-5-10
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pubmed:meshHeading |
pubmed-meshheading:17657162-Atherosclerosis,
pubmed-meshheading:17657162-Cell Adhesion,
pubmed-meshheading:17657162-Cells, Cultured,
pubmed-meshheading:17657162-Coronary Vessels,
pubmed-meshheading:17657162-Dose-Response Relationship, Drug,
pubmed-meshheading:17657162-Endothelial Cells,
pubmed-meshheading:17657162-Fatty Acids, Monounsaturated,
pubmed-meshheading:17657162-Humans,
pubmed-meshheading:17657162-Hydroxymethylglutaryl-CoA Reductase Inhibitors,
pubmed-meshheading:17657162-Indoles,
pubmed-meshheading:17657162-Intercellular Adhesion Molecule-1,
pubmed-meshheading:17657162-Leukocytes,
pubmed-meshheading:17657162-Lovastatin,
pubmed-meshheading:17657162-NF-kappa B,
pubmed-meshheading:17657162-Nicotine,
pubmed-meshheading:17657162-Nicotinic Agonists,
pubmed-meshheading:17657162-Pravastatin,
pubmed-meshheading:17657162-Protein Kinase C,
pubmed-meshheading:17657162-RNA, Messenger,
pubmed-meshheading:17657162-Reactive Oxygen Species,
pubmed-meshheading:17657162-Signal Transduction,
pubmed-meshheading:17657162-Simvastatin,
pubmed-meshheading:17657162-Smoking,
pubmed-meshheading:17657162-Superoxide Dismutase,
pubmed-meshheading:17657162-Time Factors,
pubmed-meshheading:17657162-Vascular Cell Adhesion Molecule-1,
pubmed-meshheading:17657162-rhoA GTP-Binding Protein
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pubmed:year |
2007
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pubmed:articleTitle |
HMG-CoA reductase inhibitors reduce nicotine-induced expression of cellular adhesion molecules in cultured human coronary endothelial cells.
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pubmed:affiliation |
Division of Cardiology, University of Naples Federico II, Naples, Italy. pcirillo@unina.it
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pubmed:publicationType |
Journal Article
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