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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2007-9-20
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pubmed:abstractText |
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a multi-system disorder characterized by progressive cyst formation in the kidneys. Serious complications of ADPKD are intracranial and aortic aneurysms. The condition is mainly caused by mutations in the PKD1 or PKD2 gene. We have carefully analyzed vascular remodeling in hypomorphic Pkd1(nl/nL) mouse model with dissecting aneurysms in the aorta.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1524-4636
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2177-83
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pubmed:meshHeading |
pubmed-meshheading:17656674-Aneurysm, Dissecting,
pubmed-meshheading:17656674-Animals,
pubmed-meshheading:17656674-Aorta,
pubmed-meshheading:17656674-Aortic Aneurysm,
pubmed-meshheading:17656674-Disease Models, Animal,
pubmed-meshheading:17656674-Disease Progression,
pubmed-meshheading:17656674-Endothelial Cells,
pubmed-meshheading:17656674-Extracellular Matrix,
pubmed-meshheading:17656674-Genotype,
pubmed-meshheading:17656674-Mice,
pubmed-meshheading:17656674-Mice, Inbred C57BL,
pubmed-meshheading:17656674-Mice, Knockout,
pubmed-meshheading:17656674-Mutation,
pubmed-meshheading:17656674-Myocytes, Smooth Muscle,
pubmed-meshheading:17656674-Phenotype,
pubmed-meshheading:17656674-Polycystic Kidney Diseases,
pubmed-meshheading:17656674-RNA, Messenger,
pubmed-meshheading:17656674-Severity of Illness Index,
pubmed-meshheading:17656674-TRPP Cation Channels,
pubmed-meshheading:17656674-Tunica Intima,
pubmed-meshheading:17656674-Tunica Media
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pubmed:year |
2007
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pubmed:articleTitle |
Pathogenic sequence for dissecting aneurysm formation in a hypomorphic polycystic kidney disease 1 mouse model.
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pubmed:affiliation |
Center for Human and Clinical Genetics, Leiden University Medical Center, Postal zone: S-04-P, P.O. Box 9600, 2300 RC, Leiden, The Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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