Linked Life Data

17655958

Source:http://linkedlifedata.com/resource/pubmed/id/17655958

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2007-9-25
pubmed:abstractText
Neural activities trigger regional vasodilation in the brain. Diffusible messengers such as nitric oxide (NO) and prostanoids are considered to work as vasodilators in neurovascular coupling. However, their roles are still controversial. In the present study, cortical images of neural activities and vasodilation were recorded through the intact skull of C57BL/6 mice anesthetized with urethane. Flavoprotein fluorescence responses elicited by vibratory hindpaw stimulation were followed by darkening of arteriole images reflecting vasodilation in the somatosensory cortex. Vasodilation was also observed in light reflection images at the wavelength of 570 nm in the same mice. We perfused the surface of the cortex under the skull with 100 microM N(G)-nitro-l-arginine (l-NA), an inhibitor of NO synthase (NOS), and 10 microM indomethacin, an inhibitor of cyclooxygenase (COX). These drugs suppressed vasodilation without changing flavoprotein fluorescence responses. A mixture of l-NA and indomethacin almost completely eliminated vasodilation. In mice lacking neuronal NOS (nNOS), activity-dependent vasodilation was significantly suppressed compared with that in littermate control mice, while that in mice lacking cytosolic phospholipase A2 alpha (cPLA2alpha) was unchanged. These results indicate that NO works as a vasodilator in neurovascular coupling of the mouse somatosensory cortex.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0168-0102
pubmed:author
pubmed:issnType
Print
pubmed:volume
59
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
160-71
pubmed:meshHeading
pubmed-meshheading:17655958-Animals, pubmed-meshheading:17655958-Cerebral Arteries, pubmed-meshheading:17655958-Cerebrovascular Circulation, pubmed-meshheading:17655958-Cyclooxygenase 2 Inhibitors, pubmed-meshheading:17655958-Evoked Potentials, Somatosensory, pubmed-meshheading:17655958-Flavoproteins, pubmed-meshheading:17655958-Fluorescent Dyes, pubmed-meshheading:17655958-Group IV Phospholipases A2, pubmed-meshheading:17655958-Hyperemia, pubmed-meshheading:17655958-Male, pubmed-meshheading:17655958-Mice, pubmed-meshheading:17655958-Mice, Inbred C57BL, pubmed-meshheading:17655958-Mice, Knockout, pubmed-meshheading:17655958-Nitric Oxide, pubmed-meshheading:17655958-Nitric Oxide Synthase Type I, pubmed-meshheading:17655958-Nitroarginine, pubmed-meshheading:17655958-Physical Stimulation, pubmed-meshheading:17655958-Somatosensory Cortex, pubmed-meshheading:17655958-Vasodilation
pubmed:year
2007
pubmed:articleTitle
Roles of nitric oxide as a vasodilator in neurovascular coupling of mouse somatosensory cortex.
pubmed:affiliation
Department of Neurophysiology, Brain Research Institute, Niigata University, Asahi-machi, Chuo-ku, Niigata 951-8585, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't