| pubmed-article:17652381 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17652381 | lifeskim:mentions | umls-concept:C0029341 | lld:lifeskim |
| pubmed-article:17652381 | lifeskim:mentions | umls-concept:C0016627 | lld:lifeskim |
| pubmed-article:17652381 | lifeskim:mentions | umls-concept:C1417510 | lld:lifeskim |
| pubmed-article:17652381 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:17652381 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:17652381 | lifeskim:mentions | umls-concept:C1615608 | lld:lifeskim |
| pubmed-article:17652381 | lifeskim:mentions | umls-concept:C0205250 | lld:lifeskim |
| pubmed-article:17652381 | pubmed:issue | 19 | lld:pubmed |
| pubmed-article:17652381 | pubmed:dateCreated | 2007-9-14 | lld:pubmed |
| pubmed-article:17652381 | pubmed:abstractText | Mice carrying a wild-type Mx1 gene (Mx1+/+) differ from standard laboratory mice (Mx1-/-) in being highly resistant to infection with common laboratory strains of influenza A virus. We report that Mx1 also protects mice against the pandemic human 1918 influenza virus and a highly lethal human H5N1 strain from Vietnam. Resistance to H5N1 of Mx1+/+ but not Mx1-/- mice was enhanced if the animals were treated with a single dose of exogenous alpha interferon before infection. Thus, the interferon-induced resistance factor Mx1 represents a key component of the murine innate immune system that mediates protection against epidemic and pandemic influenza viruses. | lld:pubmed |
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| pubmed-article:17652381 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:17652381 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17652381 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17652381 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:17652381 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:17652381 | pubmed:author | pubmed-author:StaeheliPeter... | lld:pubmed |
| pubmed-article:17652381 | pubmed:author | pubmed-author:García-Sastre... | lld:pubmed |
| pubmed-article:17652381 | pubmed:author | pubmed-author:KatzJacquelin... | lld:pubmed |
| pubmed-article:17652381 | pubmed:author | pubmed-author:HallerOttoO | lld:pubmed |
| pubmed-article:17652381 | pubmed:author | pubmed-author:KochsGeorgG | lld:pubmed |
| pubmed-article:17652381 | pubmed:author | pubmed-author:Van... | lld:pubmed |
| pubmed-article:17652381 | pubmed:author | pubmed-author:TumpeyTerrenc... | lld:pubmed |
| pubmed-article:17652381 | pubmed:author | pubmed-author:SzretterKrist... | lld:pubmed |
| pubmed-article:17652381 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17652381 | pubmed:volume | 81 | lld:pubmed |
| pubmed-article:17652381 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17652381 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17652381 | pubmed:pagination | 10818-21 | lld:pubmed |
| pubmed-article:17652381 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:17652381 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17652381 | pubmed:articleTitle | The Mx1 gene protects mice against the pandemic 1918 and highly lethal human H5N1 influenza viruses. | lld:pubmed |
| pubmed-article:17652381 | pubmed:affiliation | Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. tft9@cdc.gov | lld:pubmed |
| pubmed-article:17652381 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17652381 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:17652381 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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