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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
19
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pubmed:dateCreated |
2007-9-14
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pubmed:abstractText |
Mice carrying a wild-type Mx1 gene (Mx1+/+) differ from standard laboratory mice (Mx1-/-) in being highly resistant to infection with common laboratory strains of influenza A virus. We report that Mx1 also protects mice against the pandemic human 1918 influenza virus and a highly lethal human H5N1 strain from Vietnam. Resistance to H5N1 of Mx1+/+ but not Mx1-/- mice was enhanced if the animals were treated with a single dose of exogenous alpha interferon before infection. Thus, the interferon-induced resistance factor Mx1 represents a key component of the murine innate immune system that mediates protection against epidemic and pandemic influenza viruses.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17652381-15016548,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17652381-1548781,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17652381-15577936,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17652381-15716562,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17652381-16064053,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17652381-16140756,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17652381-16210530,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17652381-17426143,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17652381-17428885,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17652381-2481229,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17652381-2541210,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17652381-2903437,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17652381-3000619,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17652381-3881442,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17652381-429960,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17652381-6171385
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
81
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
10818-21
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:17652381-Animals,
pubmed-meshheading:17652381-Disease Outbreaks,
pubmed-meshheading:17652381-GTP-Binding Proteins,
pubmed-meshheading:17652381-Humans,
pubmed-meshheading:17652381-Influenza, Human,
pubmed-meshheading:17652381-Influenza A Virus, H5N1 Subtype,
pubmed-meshheading:17652381-Mice,
pubmed-meshheading:17652381-Mice, Inbred BALB C,
pubmed-meshheading:17652381-Mice, Mutant Strains
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pubmed:year |
2007
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pubmed:articleTitle |
The Mx1 gene protects mice against the pandemic 1918 and highly lethal human H5N1 influenza viruses.
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pubmed:affiliation |
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. tft9@cdc.gov
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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