Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
31
pubmed:dateCreated
2007-8-1
pubmed:databankReference
pubmed:abstractText
Leukemia inhibitory factor (LIF) receptor is a cell surface receptor that mediates the actions of LIF and other IL-6 type cytokines through the formation of high-affinity signaling complexes with gp130. Here we present the crystal structure of a complex of mouse LIF receptor with human LIF at 4.0 A resolution. The structure is, to date, the largest cytokine receptor fragment determined by x-ray crystallography. The binding of LIF to its receptor via the central Ig-like domain is unlike other cytokine receptor complexes that bind ligand predominantly through their cytokine-binding modules. This structure, in combination with previous crystallographic studies, also provides a structural template to understand the formation and orientation of the high-affinity signaling complex between LIF, LIF receptor, and gp130.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/17652170-10835339, http://linkedlifedata.com/resource/pubmed/commentcorrection/17652170-12047380, http://linkedlifedata.com/resource/pubmed/commentcorrection/17652170-12461182, http://linkedlifedata.com/resource/pubmed/commentcorrection/17652170-12529546, http://linkedlifedata.com/resource/pubmed/commentcorrection/17652170-12601009, http://linkedlifedata.com/resource/pubmed/commentcorrection/17652170-12707269, http://linkedlifedata.com/resource/pubmed/commentcorrection/17652170-12829785, http://linkedlifedata.com/resource/pubmed/commentcorrection/17652170-1425017, http://linkedlifedata.com/resource/pubmed/commentcorrection/17652170-14527405, http://linkedlifedata.com/resource/pubmed/commentcorrection/17652170-1522892, http://linkedlifedata.com/resource/pubmed/commentcorrection/17652170-15299926, http://linkedlifedata.com/resource/pubmed/commentcorrection/17652170-1549776, http://linkedlifedata.com/resource/pubmed/commentcorrection/17652170-15572765, http://linkedlifedata.com/resource/pubmed/commentcorrection/17652170-1587813, http://linkedlifedata.com/resource/pubmed/commentcorrection/17652170-15895091, http://linkedlifedata.com/resource/pubmed/commentcorrection/17652170-7961984, http://linkedlifedata.com/resource/pubmed/commentcorrection/17652170-8020098, http://linkedlifedata.com/resource/pubmed/commentcorrection/17652170-8156996, http://linkedlifedata.com/resource/pubmed/commentcorrection/17652170-8263940, http://linkedlifedata.com/resource/pubmed/commentcorrection/17652170-8272873, http://linkedlifedata.com/resource/pubmed/commentcorrection/17652170-8662595, http://linkedlifedata.com/resource/pubmed/commentcorrection/17652170-8692262, http://linkedlifedata.com/resource/pubmed/commentcorrection/17652170-8833034, http://linkedlifedata.com/resource/pubmed/commentcorrection/17652170-9271090, http://linkedlifedata.com/resource/pubmed/commentcorrection/17652170-9295349, http://linkedlifedata.com/resource/pubmed/commentcorrection/17652170-9501088, http://linkedlifedata.com/resource/pubmed/commentcorrection/17652170-9593715, http://linkedlifedata.com/resource/pubmed/commentcorrection/17652170-9757107
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:day
31
pubmed:volume
104
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
12737-42
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
An unusual cytokine:Ig-domain interaction revealed in the crystal structure of leukemia inhibitory factor (LIF) in complex with the LIF receptor.
pubmed:affiliation
The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural