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17651968
Source:
http://linkedlifedata.com/resource/pubmed/id/17651968
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rdf:type
pubmed:Citation
lifeskim:mentions
umls-concept:C0038477
,
umls-concept:C0140283
,
umls-concept:C0205177
,
umls-concept:C0205314
,
umls-concept:C0205531
,
umls-concept:C0220781
,
umls-concept:C0226896
,
umls-concept:C0243076
,
umls-concept:C0376607
,
umls-concept:C0442027
,
umls-concept:C0679622
,
umls-concept:C1148772
,
umls-concept:C1527415
,
umls-concept:C1883254
pubmed:issue
17
pubmed:dateCreated
2007-8-7
pubmed:abstractText
A series of diazepinylbenzoic acid derivatives were synthesized and tested in the inhibition assay of the transactivation of RXR. Oral treatment of cyano derivatives (16f) was found to show anti-diabetic and anti-obesity effects in KK-A(y) mice.
pubmed:language
eng
pubmed:journal
http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Obesity Agents
,
http://linkedlifedata.com/resource/pubmed/chemical/Dietary Fats
,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoglycemic Agents
,
http://linkedlifedata.com/resource/pubmed/chemical/Retinoid X Receptor alpha
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0960-894X
pubmed:author
pubmed-author:AraiYoshieY
,
pubmed-author:FukayaHiroakiH
,
pubmed-author:GunjiHirokiH
,
pubmed-author:KanazawaTakanoriT
,
pubmed-author:KimuraMasaakiM
,
pubmed-author:KishidaMasashiM
,
pubmed-author:KonishiKazuhideK
,
pubmed-author:MatsumotoYukiY
,
pubmed-author:MitaniHironobuH
,
pubmed-author:SakakiJunichiJ
,
pubmed-author:ToyaoAtsushiA
,
pubmed-author:UchiyamaHidefumiH
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4804-7
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:17651968-Animals
,
pubmed-meshheading:17651968-Anti-Obesity Agents
,
pubmed-meshheading:17651968-Body Weight
,
pubmed-meshheading:17651968-Dietary Fats
,
pubmed-meshheading:17651968-Drug Design
,
pubmed-meshheading:17651968-Hypoglycemic Agents
,
pubmed-meshheading:17651968-Inhibitory Concentration 50
,
pubmed-meshheading:17651968-Male
,
pubmed-meshheading:17651968-Mice
,
pubmed-meshheading:17651968-Mice, Transgenic
,
pubmed-meshheading:17651968-Models, Chemical
,
pubmed-meshheading:17651968-Retinoid X Receptor alpha
,
pubmed-meshheading:17651968-Structure-Activity Relationship
,
pubmed-meshheading:17651968-Transcriptional Activation
pubmed:year
2007
pubmed:articleTitle
Synthesis and structure-activity relationship of novel RXR antagonists: orally active anti-diabetic and anti-obesity agents.
pubmed:affiliation
Novartis Institute for Biomedical Research, Tsukuba Research Institute, Ohkubo 8, Tsukuba-Shi, Ibaraki, Japan.
pubmed:publicationType
Journal Article