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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2007-10-8
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pubmed:abstractText |
Kidney samples of male Fischer 344 (F-344) rats fed a carcinogenic dose of OTA over 7 days, 21 days and 12 months were analysed for various cell signalling proteins known to be potentially involved in chemical carcinogenicity. OTA was found to increase the phosphorylation of atypical-PKC. This was correlated with a selective downstream activation of the MAP-kinase extracellular regulated kinases isoforms 1 and 2 (ERK1/2) and of their substrates ELK1/2 and p90RSK. Moreover, analysis of effectors acting upstream of PKC indicated a possible mobilisation of the insulin-like growth factor-1 receptor (lGFr) and phosphoinositide-dependent kinase-1 (PDK1) system. An increased histone deacetylase (HDAC) enzymatic activity associated with enhanced HDAC3 protein expression was also observed. These findings are potentially relevant with respect to the understanding of OTA nephrocarcinogenicity. HDAC-induced gene silencing has previously been shown to play a role in tumour development. Furthermore, PKC and the MEK-ERK MAP-kinase pathways are known to play important roles in cell proliferation, cell survival, anti-apoptotic activity and renal cancer development.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3-phosphoinositide-dependent...,
http://linkedlifedata.com/resource/pubmed/chemical/Carcinogens,
http://linkedlifedata.com/resource/pubmed/chemical/Elk1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Histone Deacetylases,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Ochratoxins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, IGF Type 1,
http://linkedlifedata.com/resource/pubmed/chemical/Ribosomal Protein S6 Kinases, 90-kDa,
http://linkedlifedata.com/resource/pubmed/chemical/ets-Domain Protein Elk-1,
http://linkedlifedata.com/resource/pubmed/chemical/histone deacetylase 3,
http://linkedlifedata.com/resource/pubmed/chemical/ochratoxin A
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0041-008X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
224
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
174-81
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17651772-Animals,
pubmed-meshheading:17651772-Blotting, Western,
pubmed-meshheading:17651772-Carcinogens,
pubmed-meshheading:17651772-Gene Expression Regulation,
pubmed-meshheading:17651772-Histone Deacetylases,
pubmed-meshheading:17651772-Kidney,
pubmed-meshheading:17651772-Kidney Neoplasms,
pubmed-meshheading:17651772-MAP Kinase Signaling System,
pubmed-meshheading:17651772-Male,
pubmed-meshheading:17651772-Mitogen-Activated Protein Kinase 1,
pubmed-meshheading:17651772-Mitogen-Activated Protein Kinase 3,
pubmed-meshheading:17651772-Ochratoxins,
pubmed-meshheading:17651772-Phosphorylation,
pubmed-meshheading:17651772-Protein-Serine-Threonine Kinases,
pubmed-meshheading:17651772-Rats,
pubmed-meshheading:17651772-Rats, Inbred F344,
pubmed-meshheading:17651772-Receptor, IGF Type 1,
pubmed-meshheading:17651772-Ribosomal Protein S6 Kinases, 90-kDa,
pubmed-meshheading:17651772-Time Factors,
pubmed-meshheading:17651772-ets-Domain Protein Elk-1
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pubmed:year |
2007
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pubmed:articleTitle |
MAPK-ERK activation in kidney of male rats chronically fed ochratoxin A at a dose causing a significant incidence of renal carcinoma.
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pubmed:affiliation |
Nestlé Research Center, PO Box 44, Vers-chez-les-Blanc, CH-1000 Lausanne 26, Switzerland. maricel.marin-kuan@rdls.nestle.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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