Linked Life Data

1765142

Source:http://linkedlifedata.com/resource/pubmed/id/1765142

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-3
pubmed:dateCreated
1992-2-20
pubmed:abstractText
The pX sequence of human T cell leukemia virus type 1 (HTLV-1) has been thought to be expressed as a doubly spliced mRNA that codes for p40tax, p27rex and p21X. However, we identified a novel alternatively spliced mRNA in the HTLV-1 infected cells by using reverse transcription followed by the polymerase chain reaction. This mRNA contains only the first and third exons of the doubly spliced mRNA and encodes only p21X. Our data that this mRNA is responsible for expressing p21X exists in most of HTLV-1 infected cells strongly suggests that p21X may play a crucial role for HTLV-1 replication.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0014-5793
pubmed:author
pubmed:issnType
Print
pubmed:day
16
pubmed:volume
295
pubmed:geneSymbol
rex, tax
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
127-34
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed-meshheading:1765142-Base Sequence, pubmed-meshheading:1765142-Blotting, Southern, pubmed-meshheading:1765142-Cell Line, pubmed-meshheading:1765142-Cloning, Molecular, pubmed-meshheading:1765142-Gene Products, rex, pubmed-meshheading:1765142-Gene Products, tax, pubmed-meshheading:1765142-Human T-lymphotropic virus 1, pubmed-meshheading:1765142-Humans, pubmed-meshheading:1765142-Molecular Sequence Data, pubmed-meshheading:1765142-Oligodeoxyribonucleotides, pubmed-meshheading:1765142-Oligonucleotide Probes, pubmed-meshheading:1765142-Polymerase Chain Reaction, pubmed-meshheading:1765142-RNA, Messenger, pubmed-meshheading:1765142-RNA, Viral, pubmed-meshheading:1765142-RNA Splicing, pubmed-meshheading:1765142-Retroviridae Proteins, Oncogenic, pubmed-meshheading:1765142-Transcription, Genetic
pubmed:year
1991
pubmed:articleTitle
A novel alternatively spliced viral mRNA transcribed in cells infected with human T cell leukemia virus type 1 is mainly responsible for expressing p21X protein.
pubmed:affiliation
Shionogi Institute for Medical Science, Osaka, Japan.
pubmed:publicationType
Journal Article