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rdf:type |
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|
lifeskim:mentions |
|
|
pubmed:issue |
8
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|
pubmed:dateCreated |
2007-7-26
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|
pubmed:abstractText |
Back-titration of inhaled corticosteroid (ICS) dose in well-controlled asthma patients is emphasized in clinical guidelines, but there are few published data on the airway cell and cytokine changes in relation to ICS reduction. In our study, 20 mild-to-moderate persistent (inspite of low-moderate dose ICS treatment) asthmatic subjects prospectively rendered largely asymptomatic by high-dose ICS were assessed again by clinical, physiological, and airway inflammatory indices after 4-8 weeks of reduced ICS treatment. We aimed at assessing the underlying pathological changes in relation to clinical deterioration.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Aug
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|
pubmed:issn |
0954-7894
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
37
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|
pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
1189-98
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|
pubmed:dateRevised |
2008-4-5
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pubmed:meshHeading |
pubmed-meshheading:17651149-Adrenal Cortex Hormones,
pubmed-meshheading:17651149-Adult,
pubmed-meshheading:17651149-Aged,
pubmed-meshheading:17651149-Asthma,
pubmed-meshheading:17651149-Biological Markers,
pubmed-meshheading:17651149-Biopsy,
pubmed-meshheading:17651149-Bronchoalveolar Lavage Fluid,
pubmed-meshheading:17651149-Chemokine CCL11,
pubmed-meshheading:17651149-Chemokines, CC,
pubmed-meshheading:17651149-Female,
pubmed-meshheading:17651149-Humans,
pubmed-meshheading:17651149-Interleukin-5,
pubmed-meshheading:17651149-Leukocytes,
pubmed-meshheading:17651149-Male,
pubmed-meshheading:17651149-Middle Aged,
pubmed-meshheading:17651149-Monitoring, Physiologic,
pubmed-meshheading:17651149-Peak Expiratory Flow Rate,
pubmed-meshheading:17651149-Pulmonary Eosinophilia,
pubmed-meshheading:17651149-Spirometry
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|
pubmed:year |
2007
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|
pubmed:articleTitle |
Airway cell and cytokine changes in early asthma deterioration after inhaled corticosteroid reduction.
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|
pubmed:affiliation |
Respiratory Research Group, Menzies Research Institute, University of Tasmania, Hobart, Tasmania, Australia. yhkhor@utas.edu.au
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pubmed:publicationType |
Journal Article,
Comparative Study,
Randomized Controlled Trial
|
