Source:http://linkedlifedata.com/resource/pubmed/id/17650292
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
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| pubmed:dateCreated |
2007-7-25
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| pubmed:abstractText |
Adiponectin possesses anti-inflammatory, insulin-sensitizing and anti-atherosclerotic properties. The aim of this study was to assess the levels of serum adiponectin in patients with chronic viral hepatitis C and B and correlate them with parameters exploring insulin resistance and indices of chronic liver disease. Seventy-two patients with chronic hepatitis C virus (HCV) infection and 73 patients with chronic hepatitis B virus (HBV) infection, matched for age and sex, were studied. All individuals were examined for serum concentrations of adiponectin, insulin, C-peptide and homeostasis model assessment for insulin resistance (HOMA-IR). Viral parameters and liver histology were also evaluated. Serum adiponectin levels were significantly higher in HCV compared with HBV-infected patients. Correlation analysis in the whole group demonstrated that serum adiponectin was positively correlated with aspartate aminotransferase, alkaline phosphatase, globulins, high-density lipoprotein cholesterol and staging score, while it was negatively correlated with body mass index, insulin, C-peptide and HOMA-IR. Logistic regression analysis identified type of infection (HCV vs HBV), alcohol consumption more than 25 g daily, serum total globulin and low C-peptide as significant predictive variables associated with high adiponectin levels. Higher levels of serum adiponectin in HCV compared with HBV patients could have a role in the slower disease progression of chronic HCV infection. In addition, alcohol intake more than 25 g daily seems to be a significant predictor for hyperadiponectinaemia in patients with chronic viral hepatitis C or B. Finally, in this study, a clear positive association between adiponectin and hepatic necroinflammation or staging score was not found.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adiponectin,
http://linkedlifedata.com/resource/pubmed/chemical/Alkaline Phosphatase,
http://linkedlifedata.com/resource/pubmed/chemical/Aspartate Aminotransferases,
http://linkedlifedata.com/resource/pubmed/chemical/C-Reactive Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Globulins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Triglycerides,
http://linkedlifedata.com/resource/pubmed/chemical/gamma-Glutamyltransferase
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| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
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| pubmed:issn |
1352-0504
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
14
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
577-83
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| pubmed:meshHeading |
pubmed-meshheading:17650292-Adiponectin,
pubmed-meshheading:17650292-Alkaline Phosphatase,
pubmed-meshheading:17650292-Aspartate Aminotransferases,
pubmed-meshheading:17650292-Biopsy,
pubmed-meshheading:17650292-C-Reactive Protein,
pubmed-meshheading:17650292-Cholesterol,
pubmed-meshheading:17650292-DNA, Viral,
pubmed-meshheading:17650292-Female,
pubmed-meshheading:17650292-Globulins,
pubmed-meshheading:17650292-Hepacivirus,
pubmed-meshheading:17650292-Hepatitis B, Chronic,
pubmed-meshheading:17650292-Hepatitis B virus,
pubmed-meshheading:17650292-Hepatitis C, Chronic,
pubmed-meshheading:17650292-Histocytochemistry,
pubmed-meshheading:17650292-Humans,
pubmed-meshheading:17650292-Insulin Resistance,
pubmed-meshheading:17650292-Male,
pubmed-meshheading:17650292-Middle Aged,
pubmed-meshheading:17650292-RNA, Viral,
pubmed-meshheading:17650292-Triglycerides,
pubmed-meshheading:17650292-gamma-Glutamyltransferase
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| pubmed:year |
2007
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| pubmed:articleTitle |
Serum adiponectin in chronic hepatitis C and B.
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| pubmed:affiliation |
Department of Internal Medicine, Patras University Hospital, Patras, Greece. dsiagris@altecnet.gr
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| pubmed:publicationType |
Journal Article
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