|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
17
|
|
pubmed:dateCreated |
2007-8-16
|
|
pubmed:abstractText |
A new series of hydrophilic, lipophilic, and amphiphilic alpha-phenyl-N-tert-butylnitrone (PBN) derivatives were synthesized to explore the relationship between their hydrophilic-lipophilic properties and antioxidant potency. Very potent protective effects of amphiphilic lactobionamide and tris(hydroxymethyl)aminomethane PBN derivatives were observed in mitochondrial preparations, in cell cultures, and in rotifers exposed to unspecific and mitochondria targeted oxidotoxins.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
0022-2623
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
23
|
|
pubmed:volume |
50
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
3976-9
|
|
pubmed:meshHeading |
pubmed-meshheading:17649989-Animals,
pubmed-meshheading:17649989-Antioxidants,
pubmed-meshheading:17649989-Cells, Cultured,
pubmed-meshheading:17649989-Cyclic N-Oxides,
pubmed-meshheading:17649989-Disaccharides,
pubmed-meshheading:17649989-Drug Design,
pubmed-meshheading:17649989-Electron Transport Complex I,
pubmed-meshheading:17649989-Nitrogen Oxides,
pubmed-meshheading:17649989-Rats,
pubmed-meshheading:17649989-Rotifera,
pubmed-meshheading:17649989-Structure-Activity Relationship,
pubmed-meshheading:17649989-Submitochondrial Particles,
pubmed-meshheading:17649989-Tromethamine
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
Fine-tuning the amphiphilicity: a crucial parameter in the design of potent alpha-phenyl-N-tert-butylnitrone analogues.
|
|
pubmed:affiliation |
Laboratoire de Chimie BioOrganique et des Systèmes Moléculaires Vectoriels, Faculté des Sciences, Université d'Avignon et des Pays de Vaucluse, 33 Rue Louis Pasteur, 84000 Avignon, France.
|
|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|
