Source:http://linkedlifedata.com/resource/pubmed/id/17649958
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2007-7-25
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pubmed:abstractText |
To determine the prevalence of delta-aminolevulinic acid dehydratase (ALAD) polymorphism and its effects on blood lead levels (BLLs) in Thai workers, the authors performed a cross-sectional analysis of 389 Thai workers who were exposed to lead in a battery plant. The authors collected blood for BLLs and genotypic study, and they found that the allele frequencies of ALAD1 and ALAD2 were 0.98 and 0.02, respectively. They made a comparison of BLLs between genotype by dividing the levels into 2 categories of lead exposure (high and medium magnitude of exposure) and using length of employment as a covariance. Their results showed no significant difference of BLLs between the ALAD1-1 and ALAD1-2/ALAD2-2 groups in both levels of exposure. The frequency of ALAD2 in Thai workers was low; the authors found that ALAD polymorphism had a small or only modest effect on BLLs.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
1933-8244
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
61
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
67-72
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pubmed:dateRevised |
2008-5-28
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pubmed:meshHeading |
pubmed-meshheading:17649958-Adult,
pubmed-meshheading:17649958-Base Sequence,
pubmed-meshheading:17649958-Cross-Sectional Studies,
pubmed-meshheading:17649958-Humans,
pubmed-meshheading:17649958-Lead,
pubmed-meshheading:17649958-Polymerase Chain Reaction,
pubmed-meshheading:17649958-Polymorphism, Genetic,
pubmed-meshheading:17649958-Porphobilinogen Synthase,
pubmed-meshheading:17649958-Thailand
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pubmed:articleTitle |
Polymorphism of delta-aminolevulinic acid dehydratase and its effect on blood lead levels in Thai workers.
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pubmed:affiliation |
Faculty of Medicine at Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. rawwn@mahidol.ac.th
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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