| pubmed-article:17645941 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17645941 | lifeskim:mentions | umls-concept:C0031809 | lld:lifeskim |
| pubmed-article:17645941 | lifeskim:mentions | umls-concept:C0011923 | lld:lifeskim |
| pubmed-article:17645941 | lifeskim:mentions | umls-concept:C0025936 | lld:lifeskim |
| pubmed-article:17645941 | lifeskim:mentions | umls-concept:C0521447 | lld:lifeskim |
| pubmed-article:17645941 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:17645941 | lifeskim:mentions | umls-concept:C0162404 | lld:lifeskim |
| pubmed-article:17645941 | pubmed:issue | 30 | lld:pubmed |
| pubmed-article:17645941 | pubmed:dateCreated | 2007-8-13 | lld:pubmed |
| pubmed-article:17645941 | pubmed:abstractText | The inflammatory response is a key component in the biocompatibility of biomaterials. Among the factors that control the development of inflammation is a critical molecule nuclear factor-kappaB (NF-kappaB). Therefore, the aim of this study was to assess the feasibility of noninvasive whole-body real-time imaging for the evaluation of host-biomaterial interaction in the NF-kappaB transgenic mice. Transgenic mice, carrying the luciferase gene under the control of NF-kappaB, were constructed. In vivo bioluminescence imaging showed that the constitutive and induced NF-kappaB activities of transgenic mice were detected in most of the lymphoid tissues, demonstrating that NF-kappaB-driven luminescence reflected the inflammatory response in vivo. By the implantation of genipin-cross-linked gelatin conduit (GGC) and bacterial endotoxin-immersed GGC in the dorsal region, we detected a strong and specific luminescent signal from the tissue around the bacterial endotoxin-immersed GGC implant. Histological and immunohistochemical analysis also demonstrated that inflammation, characterized by the infiltration of immune cells, the accumulation of fluid, and the activation of NF-kappaB, was evoked around the same region. The correlation between the bioluminescence imaging and histological changes indicated that noninvasive imaging technique could be used to monitor the real-time inflammation in the implanted mice. | lld:pubmed |
| pubmed-article:17645941 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17645941 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17645941 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17645941 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17645941 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17645941 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17645941 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17645941 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17645941 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17645941 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17645941 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17645941 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:17645941 | pubmed:issn | 0142-9612 | lld:pubmed |
| pubmed-article:17645941 | pubmed:author | pubmed-author:HsiangChien-Y... | lld:pubmed |
| pubmed-article:17645941 | pubmed:author | pubmed-author:HoTin-YunTY | lld:pubmed |
| pubmed-article:17645941 | pubmed:author | pubmed-author:ChenYueh-Shen... | lld:pubmed |
| pubmed-article:17645941 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17645941 | pubmed:volume | 28 | lld:pubmed |
| pubmed-article:17645941 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17645941 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17645941 | pubmed:pagination | 4370-7 | lld:pubmed |
| pubmed-article:17645941 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:17645941 | pubmed:meshHeading | pubmed-meshheading:17645941... | lld:pubmed |
| pubmed-article:17645941 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17645941 | pubmed:articleTitle | Noninvasive nuclear factor-kappaB bioluminescence imaging for the assessment of host-biomaterial interaction in transgenic mice. | lld:pubmed |
| pubmed-article:17645941 | pubmed:affiliation | Molecular Biology Laboratory, Graduate Institute of Chinese Medical Science, China Medical University, Taichung 40402, Taiwan. | lld:pubmed |
| pubmed-article:17645941 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17645941 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17645941 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17645941 | lld:pubmed |
