Linked Life Data

17645762

Source:http://linkedlifedata.com/resource/pubmed/id/17645762

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2007-7-30
pubmed:abstractText
Studies in experimental animals have suggested that the hypocretin/orexin system may be involved in migraine pathophysiology. Using a case-control design study, we genotyped 246 migraine patients and 239 healthy controls for the 1246G-->A polymorphism of the hypocretin receptor 2 (HCRTR2) gene. Genotypic and allelic frequencies of the examined polymorphism were similarly distributed between cases and controls (chi2 = 2.22, P = 0.14 and chi2 = 2.45, P = 0.29, respectively). When different migraine subgroups were compared (migraine with aura vs. migraine without aura and episodic vs. chronic migraine) no significant difference was found. Comparison of the clinical features of the disease with the 1246G-->A genotypes showed no significant difference. Our data suggest that the HCRTR2 gene is not a genetic risk factor in migraine.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0333-1024
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
945-9
pubmed:dateRevised
2008-2-11
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
The 1246G-->A polymorphism of the HCRTR2 gene is not associated with migraine.
pubmed:affiliation
Neurology II, Headache Centre, Department of Neuroscience, University of Torino, Torino, Italy. lorenzo.pinessi@unito.it
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't