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pubmed:abstractText |
The neurotensin gene (NTS), a known dopamine modulator, is located within the candidate region for the first genetic locus of restless legs syndrome (RLS1) on chromosome 12q. Though no causative mutation was found in selected patients in a previous mutation analysis, the involvement of NTS in RLS cannot be completely excluded as a potential positional and functional candidate gene. The purpose of the current study is to further explore the NTS gene for potential functional variant(s) in its entire genomic and potential regulatory regions and their possible association with RLS symptoms.
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pubmed:affiliation |
Center for the Study of Brain Diseases, CHUM Research Center - Notre Dame Hospital, University of Montreal, Bureau Y-3616-2, 1560, rue Sherbrooke Est, Montréal, Que., Canada H2L 4MI.
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