Linked Life Data

17643266

Source:http://linkedlifedata.com/resource/pubmed/id/17643266

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2007-8-20
pubmed:abstractText
The effects of vigabatrin, which increases GABA concentrations by inhibiting GABA transaminase, on spike and wave discharges (SWDs) in the electroencephalogram of WAG/Rij rats were studied. Vigabatrin increased the incidence and duration of the SWDs, suggesting a quantitative GABA(A)ergic involvement in the mechanism(s) underlying the starting and stopping of an ongoing SWD. Also, vigabatrin decreased the SWD peak frequency, suggesting an important role of GABA(B) in the mechanism(s) underlying the peak frequency of the SWDs. Vigabatrin gradually changed the course of the hazard rates of the SWD durations, suggesting a qualitative GABAergic role in the mechanism(s) underlying the stopping of an ongoing SWD.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0920-1211
pubmed:author
pubmed:issnType
Print
pubmed:volume
76
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
34-40
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
The effects of vigabatrin on spike and wave discharges in WAG/Rij rats.
pubmed:affiliation
NICI/Department of Biological Psychology, Radboud University Nijmegen, 6500 HE Nijmegen, The Netherlands. gittebouwman@zonnet.nl
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't