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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1992-2-18
|
| pubmed:abstractText |
This study evaluated the oral toxicity of pyridostigmine bromide in Sprague-Dawley rats when administered for 13 weeks by daily gavage. Groups of 10 rats/sex received doses of 0, 5, 15, 30, or 60 mg/kg/day. Toxicity was limited to exaggerated cholinergic stimulation at doses of 15 mg/kg/day or greater. Significant findings included tremors and inhibition of RBC acetylcholinesterase. Thus, 5 mg/kg/day of pyridostigmine bromide appears to be the no observed toxic effect level under the conditions of the present investigation.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0895-3988
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
4
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
283-9
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1764218-Administration, Oral,
pubmed-meshheading:1764218-Animals,
pubmed-meshheading:1764218-Body Weight,
pubmed-meshheading:1764218-Eating,
pubmed-meshheading:1764218-Female,
pubmed-meshheading:1764218-Hematologic Tests,
pubmed-meshheading:1764218-Male,
pubmed-meshheading:1764218-Pyridostigmine Bromide,
pubmed-meshheading:1764218-Rats,
pubmed-meshheading:1764218-Rats, Inbred Strains,
pubmed-meshheading:1764218-Sex Characteristics,
pubmed-meshheading:1764218-Time Factors
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Subchronic oral toxicity of pyridostigmine bromide in rats.
|
| pubmed:affiliation |
Department of Pharmacology, University of Illinois, Chicago 60680.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.
|