Linked Life Data

17641912

Source:http://linkedlifedata.com/resource/pubmed/id/17641912

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2008-5-22
pubmed:abstractText
We report the appearance of 'poppy seed'-like structures found in the aspirated stomach contents and faeces of a 3-month-old infant receiving an omeprazole liquid via nasogastric tube, prepared by dispersing an omeprazole tablet (10 mg MUPS(R)) in water. Electron microscopy and mass spectroscopy indicated that these particles were hollow, dark purple coloured spheres comprising undissolved omeprazole and its degradation products. These observations suggest rapid degradation of omeprazole in the acid stomach contents, with compromised absorption of active drug. Consequently, dispersion of omeprazole in water may be an inappropriate formulation in this setting.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1432-1076
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
167
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
823-5
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
'Poppy seeds' in stomach aspirates: is oral omeprazole extemporaneous dispersion bioavailable?
pubmed:affiliation
Department of Pharmaceutics, The School of Pharmacy, University of London, London, UK. catherine.tuleu@pharmacy.ac.uk
pubmed:publicationType
Journal Article, Case Reports