Linked Life Data

17641407

Source:http://linkedlifedata.com/resource/pubmed/id/17641407

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2007-7-20
pubmed:abstractText
Statins can protect endothelial activation independent from their lipid-lowering effects. To gain more insight in mechanisms via which HMG-CoA inhibition may attenuate endothelial activation, we assessed the effects of mevastatin on eNOS expression of non- and modified-LDL treated endothelial cells and on basal and hydrogen peroxide-induced lipid peroxidation. Oxidized-LDL (Ox-LDL), but not glycated or acylated LDL decreased eNOS expression in human endothelial cells. The extent to which Ox-LDL decreases eNOS expression depends on the extent of modification of Ox-LDL. Mevastatin increased eNOS-expression, both in the presence and absence of Ox-LDL. In addition, mevastatin decreased the H(2)O(2)-induced (100 microM) lipid peroxidation in endothelial cells. This study shows that mevastatin has protective effects on endothelial cells by inducing eNOS and by inhibiting lipid peroxidation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1386-0291
pubmed:author
pubmed:issnType
Print
pubmed:volume
37
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
179-84
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Mevastatin increases eNO synthase expression and inhibits lipid peroxidation in human endothelial cells.
pubmed:affiliation
Department of Clinical Chemistry, Institute for Cardiovascular Research, Vrije Univeristeit Medical Center, Amsterdam, The Netherlands. C.Schalkwijk@intmed.unimass.nl
pubmed:publicationType
Journal Article