Linked Life Data

17641223

Source:http://linkedlifedata.com/resource/pubmed/id/17641223

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2007-10-29
pubmed:abstractText
This work attempts to evaluate the cognitive aspects of the acclimatization ability of mice submitted to simulated altitude. Critical altitudes were detected by evaluating open field activity, combined or not with object recognition tasks, at different acute simulated altitudes. Results showed impaired cognitive abilities at approximately 3,733 m and above. To evaluate acclimatization capabilities, mice submitted to hypobaric hypoxia at approximately 5,000 m for 1 wk were tested for learning and memory performances with classical eyeblink conditioning at the same altitude or at land altitude. Results showed total acclimatization in mice conditioned at approximately 5,000 m but no improved performance in those conditioned at land altitudes compared with controls. Selected brain sites of conditioned animals were analyzed by immunohistochemistry to detect expression of the protein product of the protooncogene c-fos (Fos) in relation to both motor learning processes and hypobaric conditions. In the nucleus of the solitary tract, a higher expression of Fos was found in the acute hypobaric conditioned animals than in control conditioned and nonconditioned animals. Similar patterns between groups were found in the other brain areas, mainly in the piriform cortex and area 1 of the cingulate cortex and in the hippocampus. Differences between hemispheres were detected only in acute hypobaric animals. The present results show that acclimatization to high altitude prevents the impairment of classical eyeblink conditioning evoked by hypobaric hypoxic conditions but does not improve this task when acquired under land conditions, although it could diminish the activation requirements for its performance.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
8750-7587
pubmed:author
pubmed:issnType
Print
pubmed:volume
103
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1479-87
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Classical eyeblink conditioning during acute hypobaric hypoxia is improved in acclimatized mice and involves Fos expression in selected brain areas.
pubmed:affiliation
Neuroscience Division, Pablo de Olavide University, Seville, Spain. jclopram@upo.es
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't