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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5840
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pubmed:dateCreated |
2007-8-17
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pubmed:abstractText |
Understanding why some people establish and maintain effective control of HIV-1 and others do not is a priority in the effort to develop new treatments for HIV/AIDS. Using a whole-genome association strategy, we identified polymorphisms that explain nearly 15% of the variation among individuals in viral load during the asymptomatic set-point period of infection. One of these is found within an endogenous retroviral element and is associated with major histocompatibility allele human leukocyte antigen (HLA)-B*5701, whereas a second is located near the HLA-C gene. An additional analysis of the time to HIV disease progression implicated two genes, one of which encodes an RNA polymerase I subunit. These findings emphasize the importance of studying human genetic variation as a guide to combating infectious agents.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17641165-10199916,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17641165-10403641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17641165-10694578,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17641165-10922055,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17641165-11309628,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17641165-12524385,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17641165-12525683,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17641165-14685052,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17641165-15167933,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17641165-15367641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17641165-16188970,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17641165-16362079,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17641165-16537629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17641165-16682496,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17641165-16763524,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17641165-16862161,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17641165-16882705,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17641165-16998491,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17641165-17041633,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17641165-17947564,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17641165-7593322,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17641165-8462994,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17641165-9412710
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/HCP5 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-B*57:01 antigen,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-B Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-C Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Immediate-Early Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNF39 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/ZNRD1 protein, human
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1095-9203
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pubmed:author |
pubmed-author:AntonarakisStylianos ESE,
pubmed-author:CastagnaAntonellaA,
pubmed-author:ColomboSaraS,
pubmed-author:CossarizzaAndreaA,
pubmed-author:Cozzi-LepriAlessandroA,
pubmed-author:De LucaAndreaA,
pubmed-author:DescombesPatrickP,
pubmed-author:EasterbrookPhilippaP,
pubmed-author:FellayJacquesJ,
pubmed-author:FrancioliPatrickP,
pubmed-author:GeDongliangD,
pubmed-author:GoldsteinDavid BDB,
pubmed-author:GumbsCurtisC,
pubmed-author:HaynesBarton FBF,
pubmed-author:LedergerberBrunoB,
pubmed-author:LetvinNorman LNL,
pubmed-author:MallalSimonS,
pubmed-author:Martinez-PicadoJavierJ,
pubmed-author:McMichaelAndrew JAJ,
pubmed-author:MiroJosé MJM,
pubmed-author:ObelNielsN,
pubmed-author:ShiannaKevin VKV,
pubmed-author:SmithJason PJP,
pubmed-author:TelentiAmalioA,
pubmed-author:WealeMikeM,
pubmed-author:WynigerJosianeJ,
pubmed-author:ZhangKunlinK
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pubmed:issnType |
Electronic
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pubmed:day |
17
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pubmed:volume |
317
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
944-7
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:17641165-Humans,
pubmed-meshheading:17641165-Female,
pubmed-meshheading:17641165-Male,
pubmed-meshheading:17641165-Disease Progression,
pubmed-meshheading:17641165-Cohort Studies,
pubmed-meshheading:17641165-Genome, Human,
pubmed-meshheading:17641165-Major Histocompatibility Complex,
pubmed-meshheading:17641165-Regression Analysis,
pubmed-meshheading:17641165-Viral Load,
pubmed-meshheading:17641165-Haplotypes,
pubmed-meshheading:17641165-Genes, MHC Class I,
pubmed-meshheading:17641165-DNA-Binding Proteins,
pubmed-meshheading:17641165-HLA-B Antigens,
pubmed-meshheading:17641165-HLA-C Antigens,
pubmed-meshheading:17641165-Immediate-Early Proteins,
pubmed-meshheading:17641165-HIV-1,
pubmed-meshheading:17641165-HIV Infections
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