Linked Life Data

17641066

Source:http://linkedlifedata.com/resource/pubmed/id/17641066

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2007-7-20
pubmed:abstractText
The induction and maintenance of T cell memory is incompletely understood, especially in humans. We have studied the T cell response and the generation of memory during acute infection by the Puumala virus (PUUV), a hantavirus endemic to Europe. It causes a self-limiting infection with no viral persistence, manifesting as hemorrhagic fever with renal syndrome. HLA tetramer staining of PBMC showed that the CD8(+) T cell response peaked at the onset of the clinical disease and decreased within the next 3 wk. Expression of activation markers on the tetramer-positive T cells was also highest during the acute phase, suggesting that the peak population consisted largely of effector cells. Despite the presence of tetramer-positive T cells expressing cytoplasmic IFN-gamma, PUUV-specific cells producing IFN-gamma in vitro were rare during the acute phase. Their frequency, as well as the expression of IL-7R alpha mRNA and surface protein, increased during a follow-up period of 6 wk and probably reflected the induction of memory T cells. Simultaneously with the PUUV-specific response, we also noted in seven of nine patients an increase in EBV-specific T cells and the transient presence of EBV DNA in three patients, indicative of viral reactivation. Our results show that in a natural human infection CD8(+) memory T cells are rare during the peak response, gradually emerging during the first weeks of convalescence. They also suggest that the boosting of unrelated memory T cells may be a common occurrence in human viral infections, which may have significant implications for the homeostasis of the memory T cell compartment.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
179
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1988-95
pubmed:dateRevised
2007-12-3
pubmed:meshHeading
pubmed-meshheading:17641066-Acute Disease, pubmed-meshheading:17641066-Adult, pubmed-meshheading:17641066-Aged, pubmed-meshheading:17641066-CD8-Positive T-Lymphocytes, pubmed-meshheading:17641066-Epitopes, T-Lymphocyte, pubmed-meshheading:17641066-Female, pubmed-meshheading:17641066-Hantavirus Infections, pubmed-meshheading:17641066-Herpesvirus 4, Human, pubmed-meshheading:17641066-Humans, pubmed-meshheading:17641066-Immunization, Secondary, pubmed-meshheading:17641066-Immunologic Memory, pubmed-meshheading:17641066-Interleukin-15 Receptor alpha Subunit, pubmed-meshheading:17641066-Kinetics, pubmed-meshheading:17641066-Lymphocyte Activation, pubmed-meshheading:17641066-Male, pubmed-meshheading:17641066-Middle Aged, pubmed-meshheading:17641066-Puumala virus, pubmed-meshheading:17641066-Receptors, Interleukin-7, pubmed-meshheading:17641066-Virus Activation
pubmed:year
2007
pubmed:articleTitle
Human CD8+ T cell memory generation in Puumala hantavirus infection occurs after the acute phase and is associated with boosting of EBV-specific CD8+ memory T cells.
pubmed:affiliation
Haartman Institute, University of Helsinki, Finland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural