17641046

Source:http://linkedlifedata.com/resource/pubmed/id/17641046

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0521026, umls-concept:C0729678, umls-concept:C1155265, umls-concept:C1510506, umls-concept:C1550548, umls-concept:C1555714, umls-concept:C1564907, umls-concept:C1705654, umls-concept:C1709305, umls-concept:C1880022
pubmed:issue	3
pubmed:dateCreated	2007-7-20
pubmed:abstractText	Sin Nombre virus (SNV) is a highly pathogenic New World virus and etiologic agent of hantavirus cardiopulmonary syndrome. We have previously shown that replication-defective virus particles are able to induce a strong IFN-stimulated gene (ISG) response in human primary cells. RNA viruses often stimulate the innate immune response by interactions between viral nucleic acids, acting as a pathogen-associated molecular pattern, and cellular pattern-recognition receptors (PRRs). Ligand binding to PRRs activates transcription factors which regulate the expression of antiviral genes, and in all systems examined thus far, IFN regulatory factor 3 (IRF3) has been described as an essential intermediate for induction of ISG expression. However, we now describe a model in which IRF3 is dispensable for the induction of ISG transcription in response to viral particles. IRF3-independent ISG transcription in human hepatoma cell lines is initiated early after exposure to SNV virus particles in an entry- and replication-independent fashion. Furthermore, using gene knockdown, we discovered that this activation is independent of the best-characterized RNA- and protein-sensing PRRs including the cytoplasmic caspase recruitment domain-containing RNA helicases and the TLRs. SNV particles engage a heretofore unrecognized PRR, likely located at the cell surface, and engage a novel IRF3-independent pathway that activates the innate immune response.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/1 T32 AI07583, http://linkedlifedata.com/resource/pubmed/grant/U01 AI054779, http://linkedlifedata.com/resource/pubmed/grant/U01 AI56618
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/2985117R
pubmed:citationSubset	AIM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/DDX58 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/DEAD-box RNA Helicases, http://linkedlifedata.com/resource/pubmed/chemical/IRF3 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/IRF7 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Interferon Regulatory Factor-3, http://linkedlifedata.com/resource/pubmed/chemical/Interferon Regulatory Factor-7, http://linkedlifedata.com/resource/pubmed/chemical/Interferons, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Virus, http://linkedlifedata.com/resource/pubmed/chemical/TLR3 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptor 3, http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptors
pubmed:status	MEDLINE
pubmed:month	Aug
pubmed:issn	0022-1767
pubmed:author	pubmed-author:Bondu-HawkinsVirginie SVS, pubmed-author:HallPamela RPR, pubmed-author:HjelleBrianB, pubmed-author:PrescottJoseph BJB, pubmed-author:YeChunyanC
pubmed:issnType	Print
pubmed:day	1
pubmed:volume	179
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	1796-802
pubmed:dateRevised	2009-11-19
pubmed:meshHeading	pubmed-meshheading:17641046-Carcinoma, Hepatocellular, pubmed-meshheading:17641046-Cell Line, Tumor, pubmed-meshheading:17641046-DEAD-box RNA Helicases, pubmed-meshheading:17641046-Gene Expression Regulation, Viral, pubmed-meshheading:17641046-Humans, pubmed-meshheading:17641046-Immunity, Innate, pubmed-meshheading:17641046-Interferon Regulatory Factor-3, pubmed-meshheading:17641046-Interferon Regulatory Factor-7, pubmed-meshheading:17641046-Interferons, pubmed-meshheading:17641046-Receptors, Virus, pubmed-meshheading:17641046-Sin Nombre virus, pubmed-meshheading:17641046-Toll-Like Receptor 3, pubmed-meshheading:17641046-Toll-Like Receptors, pubmed-meshheading:17641046-Ultraviolet Rays, pubmed-meshheading:17641046-Virion, pubmed-meshheading:17641046-Virus Internalization, pubmed-meshheading:17641046-Virus Replication
pubmed:year	2007
pubmed:articleTitle	Early innate immune responses to Sin Nombre hantavirus occur independently of IFN regulatory factor 3, characterized pattern recognition receptors, and viral entry.
pubmed:affiliation	Department of Pathology, Center for Infectious Diseases and Immunity, School of Medicine, University of New Mexico, Albuquerque, NM 87131, USA.
pubmed:publicationType	Journal Article, Research Support, N.I.H., Extramural