Source:http://linkedlifedata.com/resource/pubmed/id/17641022
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2007-7-20
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| pubmed:abstractText |
Chronic nonbacterial prostatitis is a poorly defined syndrome of putative autoimmune origin. To further understand its pathogenesis, we have analyzed autoimmune prostatitis in the NOD mouse, a strain genetically prone to develop different organ-specific autoimmune diseases. Spontaneous development of autoimmune prostatitis in the NOD male, defined by lymphomonuclear cell infiltration in the prostate gland, is well-established by approximately 20 wk of age and is stably maintained afterward. Disease development is indistinguishable in NOD and NOR mice, but is markedly delayed in IFN-gamma-deficient NOD mice. A T cell response to the prostate-specific autoantigen prostatic steroid-binding protein (PSBP) can be detected in NOD males before development of prostate infiltration, indicating lack of tolerance to this self Ag. The intraprostatic inflammatory infiltrate is characterized by Th1-type CD4(+) T cells, which are able to transfer autoimmune prostatitis into NOD.SCID recipients. We characterize here experimental autoimmune prostatitis, detected by intraprostatic infiltrate and PSBP-specific T cell responses, induced in 6- to 8-wk-old NOD males by immunization with synthetic peptides corresponding to the C1 subunit of PSBP. Three PSBP peptides induce in NOD mice vigorous T and B cell responses, paralleled by a marked lymphomononuclear cell infiltration in the prostate. Two of these peptides, PSBP(21-40) and PSBP(61-80), correspond to immunodominant self epitopes naturally processed in NOD mice after immunization with PSBP, whereas peptide PSBP(91-111) represents a cryptic epitope. These model systems address pathogenetic mechanisms in autoimmune prostatitis and will facilitate testing and mechanistic analysis of therapeutic approaches in this condition.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
|
| pubmed:issn |
0022-1767
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
179
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1559-67
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:17641022-Amino Acid Sequence,
pubmed-meshheading:17641022-Androgen-Binding Protein,
pubmed-meshheading:17641022-Animals,
pubmed-meshheading:17641022-Antigen Presentation,
pubmed-meshheading:17641022-Autoantigens,
pubmed-meshheading:17641022-Autoimmune Diseases,
pubmed-meshheading:17641022-CD4-Positive T-Lymphocytes,
pubmed-meshheading:17641022-Cell Movement,
pubmed-meshheading:17641022-Cells, Cultured,
pubmed-meshheading:17641022-Male,
pubmed-meshheading:17641022-Mice,
pubmed-meshheading:17641022-Mice, Inbred BALB C,
pubmed-meshheading:17641022-Mice, Inbred C57BL,
pubmed-meshheading:17641022-Mice, Inbred NOD,
pubmed-meshheading:17641022-Mice, SCID,
pubmed-meshheading:17641022-Molecular Sequence Data,
pubmed-meshheading:17641022-Organ Specificity,
pubmed-meshheading:17641022-Peptide Fragments,
pubmed-meshheading:17641022-Prostatein,
pubmed-meshheading:17641022-Prostatitis,
pubmed-meshheading:17641022-Rats,
pubmed-meshheading:17641022-Self Tolerance
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| pubmed:year |
2007
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| pubmed:articleTitle |
Spontaneous and prostatic steroid binding protein peptide-induced autoimmune prostatitis in the nonobese diabetic mouse.
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| pubmed:affiliation |
BioXell, Milan, Italy.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|