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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1992-2-7
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pubmed:databankReference |
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pubmed:abstractText |
alpha B-Crystallin specifically decreases in atrophied rat soleus muscle with hindlimb suspension (HS). alpha B-Crystallin cDNA was cloned from rat heart cDNA library using oligonucleotide probe, and its complete coding and partial non-coding regions were sequenced. Northern blot analysis revealed that alpha B-crystallin mRNA in slow muscle decreases at 36 hour after HS but recovered at 24 hour after HS stopped. Denervation decreased the expression of alpha B-crystallin mRNA in slow muscle but increased it in fast muscles, which hardly expressed in normal condition. Passive tension increased the expression of alpha B-crystallin mRNA in both muscle types. Based upon these Northern blot analysis of alpha B-crystallin, nerve innervation and external load on muscle are essential regulatory factors on the expression of the mRNA of alpha B-crystallin in rat skeletal muscle.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
31
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pubmed:volume |
181
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1323-30
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1764082-Actins,
pubmed-meshheading:1764082-Amino Acid Sequence,
pubmed-meshheading:1764082-Animals,
pubmed-meshheading:1764082-Atrophy,
pubmed-meshheading:1764082-Base Sequence,
pubmed-meshheading:1764082-Blotting, Northern,
pubmed-meshheading:1764082-Cloning, Molecular,
pubmed-meshheading:1764082-Crystallins,
pubmed-meshheading:1764082-DNA,
pubmed-meshheading:1764082-Gene Expression,
pubmed-meshheading:1764082-Heart,
pubmed-meshheading:1764082-Male,
pubmed-meshheading:1764082-Molecular Sequence Data,
pubmed-meshheading:1764082-Muscle Denervation,
pubmed-meshheading:1764082-Muscles,
pubmed-meshheading:1764082-Oligonucleotide Probes,
pubmed-meshheading:1764082-RNA, Messenger,
pubmed-meshheading:1764082-Rats,
pubmed-meshheading:1764082-Rats, Inbred Strains
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pubmed:year |
1991
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pubmed:articleTitle |
Early changes of alpha B-crystallin mRNA in rat skeletal muscle to mechanical tension and denervation.
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pubmed:affiliation |
Department of Sports Sciences, College of Arts & Sciences, University of Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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