17640696

Source:http://linkedlifedata.com/resource/pubmed/id/17640696

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0003451, umls-concept:C0019682, umls-concept:C0019699, umls-concept:C0037224, umls-concept:C0332324, umls-concept:C0332466, umls-concept:C0441655, umls-concept:C1423839, umls-concept:C1510438, umls-concept:C1880022, umls-concept:C1999216
pubmed:issue	1
pubmed:dateCreated	2007-10-26
pubmed:abstractText	A virus-dependent fusion assay was utilized to examine the activity of a panel of HIV-1, -2, and SIV isolates of distinct coreceptor phenotypes. This assay allowed identification of entry inhibitors, and characterization of an antagonist of a Rac guanine nucleotide exchange factor, as an inhibitor of HIV-mediated fusion.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/5-M01-RR-00722, http://linkedlifedata.com/resource/pubmed/grant/AI24745, http://linkedlifedata.com/resource/pubmed/grant/R01 AI024745-18, http://linkedlifedata.com/resource/pubmed/grant/U01-AI-35042
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pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0110674
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Guanine Nucleotide Exchange Factors, http://linkedlifedata.com/resource/pubmed/chemical/HIV Fusion Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/rac GTP-Binding Proteins
pubmed:status	MEDLINE
pubmed:month	Nov
pubmed:issn	0042-6822
pubmed:author	pubmed-author:CampbellNancyN, pubmed-author:HarmonBrookeB, pubmed-author:PontowSuzanneS, pubmed-author:RatnerLeeL
pubmed:issnType	Print
pubmed:day	10
pubmed:volume	368
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	1-6
pubmed:dateRevised	2011-9-26
pubmed:meshHeading	pubmed-meshheading:17640696-Cell Line, pubmed-meshheading:17640696-Guanine Nucleotide Exchange Factors, pubmed-meshheading:17640696-HIV Fusion Inhibitors, pubmed-meshheading:17640696-HIV-1, pubmed-meshheading:17640696-HIV-2, pubmed-meshheading:17640696-Humans, pubmed-meshheading:17640696-Simian immunodeficiency virus, pubmed-meshheading:17640696-Virus Internalization, pubmed-meshheading:17640696-rac GTP-Binding Proteins
pubmed:year	2007
pubmed:articleTitle	Antiviral activity of a Rac GEF inhibitor characterized with a sensitive HIV/SIV fusion assay.
pubmed:affiliation	Departments of Medicine and Molecular Microbiology, Washington University School of Medicine, Box 8069, 660 S Euclid Ave, St. Louis, MO 63110, USA.
pubmed:publicationType	Journal Article, Research Support, N.I.H., Extramural